Evidence map›Paper›PMID 34572882›Full record

ArticleCancers2021

Discordance of PD-L1 Expression at the Protein and RNA Levels in Early Breast Cancer.

Ioannis Zerdes, Vaia Karafousia, Artur Mezheyeuski, Maria Stogiannitsi, Raoul Kuiper, Pablo Moreno Ruiz, George Rassidakis, Jonas Bergh, Thomas Hatschek, Theodoros Foukakis and 1 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ioannis ZerdesDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Vaia KarafousiaDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Artur MezheyeuskiDepartment of Immunology, Genetics and Pathology, Uppsala University, P.O. Box 516, 751 20 Uppsala, Sweden.ORCID 0000-0002-4394-2634
Maria StogiannitsiDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Raoul KuiperDepartment of Laboratory Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Pablo Moreno RuizDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-1616-3889
George RassidakisDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Jonas BerghDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Thomas HatschekDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Theodoros FoukakisDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0001-8952-9987
Alexios MatikasDepartment of Oncology-Pathology, Karolinska Institutet, 171 77 Stockholm, Sweden.

Funding

Bröstcancerförbundet N/ACancerfonden CAN 2018/846Cancerföreningen i Stockholm 174113Percy Falks Stiftelse för Forskning Beträffande Prostata- och Bröstcancer N/AStockholms Läns Landsting K 2017-4577
6 · The paper itself

Abstract

We aimed to assess if the discrepant prognostic information between Programmed Death Ligand 1 (PD-L1) protein versus mRNA expression in early breast cancer (BC) could be attributed to heterogeneity in its expression. PD-L1 protein and mRNA expression in BC tissue microarrays from two clinical patient cohorts were evaluated (105 patients; cohort 1: untreated; cohort 2: neoadjuvant chemotherapy-treated). Immunohistochemistry (IHC) with SP142, SP263 was performed. PD-L1 mRNA was evaluated using bulk gene expression and RNA-FISH RNAscope

Indexed as

breast cancerheterogeneityin situ hybridizationmultiplex immunohistochemistryPD-L1

Identifiers

PMID34572882
PMCPMC8467035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.