Evidence map›Paper›PMID 34572850›Full record

ReviewCancers2021

A Perspective on the Role of Microbiome for Colorectal Cancer Treatment.

Sanjna Kalasabail, Jared Engelman, Linda Yun Zhang, Emad El-Omar, Howard Chi Ho Yim

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sanjna KalasabailMicrobiome Research Centre, St George and Sutherland Clinical School, The University of New South Wales, Sydney 2052, Australia.
Jared EngelmanMicrobiome Research Centre, St George and Sutherland Clinical School, The University of New South Wales, Sydney 2052, Australia.
Linda Yun ZhangMicrobiome Research Centre, St George and Sutherland Clinical School, The University of New South Wales, Sydney 2052, Australia.
Emad El-OmarMicrobiome Research Centre, St George and Sutherland Clinical School, The University of New South Wales, Sydney 2052, Australia.
Howard Chi Ho YimMicrobiome Research Centre, St George and Sutherland Clinical School, The University of New South Wales, Sydney 2052, Australia.
Sutherland Hospital · AU

Funding

Australian Government N/A
6 · The paper itself

Abstract

In healthy hosts, trillions of microbes colonise the gut and oral cavity in a well-balanced state, maintaining a mutually beneficial relationship. Loss of this balance, termed dysbiosis, is strongly implicated in the pathogenesis of colorectal cancer (CRC). However, the roles of microbiota and dysbiosis in CRC treatment remain poorly understood. Recent studies suggest that the gut microbiota has the ability to affect the host response to chemotherapeutic agents by enhancing drug efficacy, promoting chemoresistance and mediating chemotherapy-induced toxicity and side effects via a variety of mechanisms. Several other studies have also proposed manipulation of the microbiota to optimise CRC treatment. In this review, we summarise the current advancement of knowledge on how microbiota and CRC treatments interact with each other and how this interaction may shed some light on the development of personalised microbiota manipulations that improve CRC treatment outcomes.

Indexed as

5-fluorouracilcapecitabinechemotherapycolorectal canceririnotecanleucovorinmicrobiomeoxaliplatinsynbioticstoxicity

Identifiers

PMID34572850
PMCPMC8468110
OpenAlexW3200365266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.