Evidence map›Paper›PMID 34572848›Full record

ArticleCancers2021

Responses to SARS-CoV-2 Vaccination in Patients with Cancer (ReCOVer Study): A Prospective Cohort Study of the Hellenic Cooperative Oncology Group.

Helena Linardou, Nikolaos Spanakis, Georgia-Angeliki Koliou, Athina Christopoulou, Sofia Karageorgopoulou, Nephely Alevra, Anastasios Vagionas, Nikolaos Tsoukalas, Stavroula Sgourou, Elena Fountzilas and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  15. Article
  16. The Interplay of Lung Cancer, COVID-19, and Vaccines.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Longitudinal Analyses of COVID-19 Vaccination in Patients With Lung Cancer: Antibody Responses and Variant-Specific Neutralization.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  19. Article
  20. Cohort profile:BMJ open · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 2 countries.

Helena LinardouFourth Oncology Department and Comprehensive Clinical Trials Centre, Metropolitan Hospital, 18547 Athens, Greece.ORCID 0000-0002-2906-6607
Nikolaos SpanakisDepartment of Microbiology, Medical School, National and Kapodistrian University of Athens, 11524 Athens, Greece.
Georgia-Angeliki KoliouSection of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, 11526 Athens, Greece.
Athina ChristopoulouMedical Oncology Unit, S. Andrew Hospital, 26332 Patras, Greece.
Sofia KarageorgopoulouThird Department of Medical Oncology, IASO Clinic, 15123 Athens, Greece.
Nephely AlevraFourth Oncology Department and Comprehensive Clinical Trials Centre, Metropolitan Hospital, 18547 Athens, Greece.
Anastasios VagionasOncology Department, General Hospital of Kavala, 65500 Kavala, Greece.
Nikolaos TsoukalasDepartment of Oncology, 401 General Military Hospital of Athens, 11525 Athens, Greece.ORCID 0000-0002-1455-1503
Stavroula SgourouFourth Oncology Department and Comprehensive Clinical Trials Centre, Metropolitan Hospital, 18547 Athens, Greece.
Elena FountzilasSecond Department of Medical Oncology, Euromedica General Clinic of Thessaloniki, 54645 Thessaloniki, Greece.
Joseph SgourosThird Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece.
Evangelia RazisThird Department of Medical Oncology, Hygeia Hospital, 15123 Athens, Greece.
Dimitra ChatzokouAlfaLab, Hellenic HealthCare Group, 11524 Athens, Greece.
Sofia LampakiPulmonary Department, Lung Cancer Oncology Unit, Aristotle University of Thessaloniki, G. Papanicolaou Hospital, 57010 Thessaloniki, Greece.
Eleni ResThird Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece.
Zacharenia SaridakiAsklepieion Crete Clinic, Oncology Department, 71201 Heraklion, Greece.ORCID 0000-0003-2931-5797
Giannis MountziosFourth Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, 11526 Athens, Greece.ORCID 0000-0002-7780-7836
George SaroglouMedical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
George FountzilasLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8045-2186
Metropolitan Hospital · GRAristotle University of Thessaloniki · GRHospital Agioi Anargyroi · GRNational and Kapodistrian University of Athens · GR401 General Military Hospital of Athens · GRClinic Asklepio Larissa · GREuropean University Cyprus · CYGeneral University Hospital of Patras · GRHellenic Cooperative Oncology Group · GRHenry Dunant Hospital · GRHygeia Hospital · GRIASO General Hospital · GRTechnological Educational Institute of Eastern Macedonia and Thrace · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data on the effectiveness and safety of approved SARS-CoV-2 vaccines in cancer patients are limited. This observational, prospective cohort study investigated the humoral immune response to SARS-CoV-2 vaccination in 232 cancer patients from 12 HeCOG-affiliated oncology departments compared to 100 healthcare volunteers without known active cancer. The seropositivity rate was measured 2-4 weeks after two vaccine doses, by evaluating neutralising antibodies against the SARS-CoV-2 spike protein using a commercially available immunoassay. Seropositivity was defined as ≥33.8 Binding-Antibody-Units (BAU)/mL. A total of 189 patients and 99 controls were eligible for this analysis. Among patients, 171 (90.5%) were seropositive after two vaccine doses, compared to 98% of controls (

Indexed as

antibody responseanti-spikecancer patientneutralizing IgGSARS-CoV-2 vaccine

Identifiers

PMID34572848
PMCPMC8466969
OpenAlexW3200078862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.