Evidence map›Paper›PMID 34572749›Full record

ArticleCancers2021

Protein Ligands in the Secretome of CD36

Kosar Jabbari, Garrett Winkelmaier, Cody Andersen, Paul Yaswen, David Quilici, Saori Furuta, Qingsu Cheng, Bahram Parvin

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Exosome: an overview on enhanced biogenesis by small molecules.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. CD36 and Its Role in Regulating the Tumor Microenvironment.Current oncology (Toronto, Ont.) · 2022
    Review
  7. CD36International journal of molecular sciences · 2022
    Article
  8. Review
  9. Article
  10. Role of CD36 in cancer progression, stemness, and targeting.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kosar JabbariDepartment of Biomedical Engineering, University of Nevada Reno, Reno, NV 89557, USA.ORCID 0000-0003-2027-2719
Garrett WinkelmaierDepartment of Biomedical Engineering, University of Nevada Reno, Reno, NV 89557, USA.ORCID 0000-0002-2027-352X
Cody AndersenDepartment of Biomedical Engineering, University of Nevada Reno, Reno, NV 89557, USA.
Paul YaswenDepartment of Biomedical Engineering, University of Nevada Reno, Reno, NV 89557, USA.
David QuiliciNevada Proteomics Center, University of Nevada Reno, Reno, NV 89557, USA.
Saori FurutaDepartment of Cancer Biology, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0003-1121-0487
Qingsu ChengDepartment of Biomedical Engineering, University of Nevada Reno, Reno, NV 89557, USA.
Bahram ParvinDepartment of Biomedical Engineering, University of Nevada Reno, Reno, NV 89557, USA.ORCID 0000-0002-6433-8006
University of Nevada, Reno · USUniversity of Toledo · US

Funding

Normalizing arginine metabolism with sepiaptein for immunostimulatory-shift ofHER2+ breast cancerR01CA248304 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI FURUTA, SAORI · 2020 to 2024
$1.8M
Stratifying brain tumors by structural subtyping and heterogeneityR15CA235430 · NCI · UNIVERSITY OF NEVADA RENO · PI PARVIN, BAHRAM A. · 2019 to 2019
$430k
NCI NIH HHS R01 CA248304NCI NIH HHS R15 CA235430NIH HHS 1R15CA23543
6 · The paper itself

Abstract

Reprogramming the tumor stroma is an emerging approach to circumventing the challenges of conventional cancer therapies. This strategy, however, is hampered by the lack of a specific molecular target. We previously reported that stromal fibroblasts (FBs) with high expression of CD36 could be utilized for this purpose. These studies are now expanded to identify the secreted factors responsible for tumor suppression. Methodologies included 3D colonies, fluorescent microscopy coupled with quantitative techniques, proteomics profiling, and bioinformatics analysis. The results indicated that the conditioned medium (CM) of the CD36

Indexed as

3D coloniesbreast cancer cellsCD36+ fibroblastsconditioned mediumproteomics profiling

Identifiers

PMID34572749
PMCPMC8469330
OpenAlexW3196356670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.