Aerosolized Hypertonic Saline Hinders Biofilm Formation to Enhance Antibiotic Susceptibility of Multidrug-Resistant

Hui-Ling Lin, Chen-En Chiang, Mei-Chun Lin, Mei-Lan Kau, Yun-Tzu Lin, Chi-Shuo Chen

Open access · goldAbstract read

In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.2field-weighted citation impact, top 57% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

Hypertonic thermal solutions as a putative strategy for respiratory biofilm disruption.Open medicine (Warsaw, Poland) · 2026
Article
Sodium ibuprofenate: antibacterial activities and potential β-lactamase inhibition in critical Gram-negative bacteria.Future microbiology · 2025
Article
Antimicrobial Potential of Cannabinoids: A Scoping Review of the Past 5 Years.Microorganisms · 2025
Review
New Biomolecules and Drug Delivery Systems as Alternatives to Conventional Antibiotics.Antibiotics (Basel, Switzerland) · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hui-Ling LinDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0002-8268-8907

Chen-En ChiangDepartment of Respiratory Therapy, Chang Gung University, Taoyuan 33323, Taiwan.

Mei-Chun LinDepartment of Respiratory Therapy, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Mei-Lan KauDepartment of Respiratory Therapy, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Yun-Tzu LinDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.

Chi-Shuo ChenDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0001-8982-6412

Linkou Chang Gung Memorial Hospital · TWNational Tsing Hua University · TWChang Gung University · TWChang Gung University of Science and Technology · TW

Funding

Chang Gung Medical Foundation CMRPD1K0181Ministry of Science and Technology, Taiwan 109-2314-B-182-067; 109-2314-B-182-067-003

6 · The paper itself

Abstract

Limited therapeutic options are available for multidrug-resistant

Indexed as

aerosol deliveryantibioticsbiofilmhypertonic salinemultidrug-resistant Acinetobacter baumannii (MDR-AB)

Identifiers

PMID34572697

DOI10.3390/antibiotics10091115

PMCPMC8465634

OpenAlexW3200940577

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.