ReviewAntibiotics (Basel, Switzerland)2021
Antibiotics in Necrotizing Soft Tissue Infections.
Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Severe upper limb soft tissue infection with compartment syndrome following a scratch injury: a case report.Journal of medical case reports · 2026Article
- A fully human streptolysin O-neutralizing monoclonal antibody improves survival in a murine model of group A streptococcus necrotizing soft tissue infection.Antimicrobial agents and chemotherapy · 2026Article
- Prognostic value of inflammatory and metabolic markers in Fournier's gangrene: a single-center retrospective analysis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Cutaneous Mucormycosis Clinically Mimicking Necrotizing Fasciitis in a Patient Without Active Immunosuppression.Clinical case reports · 2026Article
- Periocular necrotizing fasciitis following surgical site infection in aesthetic rhinoplasty: a report of two cases.Journal of ophthalmic inflammation and infection · 2026Article
- Individualized multidisciplinary management of severe odontogenic deep neck infections with and without descending necrotizing mediastinitis: a report of two cases.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2026Article
- Spontaneous arterial rupture complicating neurofibromatosis type 1: a case report of massive lumbogluteal hematoma and literature review.Frontiers in medicine · 2026Article
- [Necrotizing fasciitis following a motorcycle accident : Case report of gas gangrene and a practical algorithm for clinical management].Unfallchirurgie (Heidelberg, Germany) · 2025Article
- Review
- Legends, dogmas, presumptions, and demystifications in antibiotic therapy.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Review
- Antibiotic therapy in necrotizing soft tissue infections: a narrative review of the greater Paris SURFAST consortium.Critical care (London, England) · 2025Review
- A Paradigm Shift in SSTI Management: The Multifunctional Role of Extracellular Vesicles.International journal of molecular sciences · 2025Review
- Optimizing Antibiotic Choice, Administration, and Duration in NSTI Treatment.Bioengineering (Basel, Switzerland) · 2025Review
- Necrotizing fasciitis of the head and neck - clinical features, diagnostics, and management strategies.Oncoscience · 2025Article
- Case Report: From septic shock to recovery - a battle against lethal necrotizing soft tissue infection.Frontiers in immunology · 2025Article
- Predicting mortality in necrotizing fasciitis: Retrospective evaluation of 69 cases.Northern clinics of Istanbul · 2025Article
- Application of Biofire Filmarray Joint Infection Panel for Rapid Identification of Aetiology in a Necrotizing Fasciitis Case.Diagnostics (Basel, Switzerland) · 2024Article
- Multidisciplinary Approach in Rare, Fulminant-Progressing, and Life-Threatening Facial Necrotizing Fasciitis.Infectious disease reports · 2024Article
- Treating necrotizing skin and soft-tissue infections.Intensive care medicine · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections characterized by an extensive necrosis of skin and subcutaneous tissues. Initial urgent management of NSTIs relies on broad-spectrum antibiotic therapy, rapid surgical debridement of all infected tissues and, when present, treatment of associated organ failures in the intensive care unit. Antibiotic therapy for NSTI patients faces several challenges and should (1) carry broad-spectrum activity against gram-positive and gram-negative pathogens because of frequent polymicrobial infections, considering extended coverage for multidrug resistance in selected cases. In practice, a broad-spectrum beta-lactam antibiotic (e.g., piperacillin-tazobactam) is the mainstay of empirical therapy; (2) decrease toxin production, typically using a clindamycin combination, mainly in proven or suspected group A streptococcus infections; and (3) achieve the best possible tissue diffusion with regards to impaired regional perfusion, tissue necrosis, and pharmacokinetic and pharmacodynamic alterations. The best duration of antibiotic treatment has not been well established and is generally comprised between 7 and 15 days. This article reviews the currently available knowledge regarding antibiotic use in NSTIs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.