Evidence map›Paper›PMID 34572671›Full record

ArticleAntibiotics (Basel, Switzerland)2021

A Combined Phenotypic-Genotypic Predictive Algorithm for In Vitro Detection of Bicarbonate: β-Lactam Sensitization among Methicillin-Resistant

Selvi C Ersoy, Warren E Rose, Robin Patel, Richard A Proctor, Henry F Chambers, Ewan M Harrison, Youngju Pak, Arnold S Bayer

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Genomic investigation and clinical correlates of theAntimicrobial agents and chemotherapy · 2024
    Trial
  2. An Achilles' heel for methicillin-resistantAntimicrobial agents and chemotherapy · 2026
    Review
  3. Phenotypic and genotypic correlates of the sodium bicarbonate-responsive phenotype among methicillin-resistant Staphylococcus aureus isolates from skin and soft-tissue infections.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025
    Article
  4. Article
  5. Review
  6. Sensitizing methicillin-resistantAntimicrobial agents and chemotherapy · 2024
    Article
  7. Role of the NaHCOMicrobiology spectrum · 2023
    Article
  8. Article
  9. Article
  10. The NaHCOAntimicrobial agents and chemotherapy · 2022
    Article
  11. Impacts of NaHCOAntibiotics (Basel, Switzerland) · 2022
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Selvi C ErsoyThe Lundquist Institute, Torrance, CA 90502, USA.ORCID 0000-0002-8792-2061
Warren E RoseSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0001-5012-5993
Robin PatelMayo Clinic, Rochester, MN 55902, USA.
Richard A ProctorSchool of Medicine and Public Health, University of Wisconsin, Madison, WI 53706-152, USA.
Henry F ChambersSchool of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Ewan M HarrisonWellcome Sanger Institute, Hinxton CB10 1SA, UK.
Youngju PakThe Lundquist Institute, Torrance, CA 90502, USA.
Arnold S BayerThe Lundquist Institute, Torrance, CA 90502, USA.ORCID 0000-0003-1968-0192
University of California, Los Angeles · USUniversity of Wisconsin–Madison · USMayo Clinic in Arizona · USUniversity of California, San Francisco · USUniversity of Cambridge · GB

Funding

Bicarbonate-Mediated Enhancement of Beta-Lactam-MRSA Killing: Mechanisms and Clinical TranslatabilityR01AI146078 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI146078NIH HHS AI132627NIH HHS AI146078
6 · The paper itself

Abstract

Antimicrobial susceptibility testing (AST) is routinely used to establish predictive antibiotic resistance metrics to guide the treatment of bacterial pathogens. Recently, a novel phenotype termed "bicarbonate (NaHCO

Indexed as

antimicrobial susceptibility testing (AST)genome sequencingmethicillin-resistant Staphylococcus aureus (MRSA)sodium bicarbonate (NaHCO3)β-lactam susceptibility

Identifiers

PMID34572671
PMCPMC8469475
OpenAlexW3198588216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.