Evidence map›Paper›PMID 34572667›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Phages for Africa: The Potential Benefit and Challenges of Phage Therapy for the Livestock Sector in Sub-Saharan Africa.

Angela Makumi, Amos Lucky Mhone, Josiah Odaba, Linda Guantai, Nicholas Svitek

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. NovelPHAGE (New Rochelle, N.Y.) · 2023
    Article
  10. Bacteriophage Therapy to Control Bovine Mastitis: A Review.Antibiotics (Basel, Switzerland) · 2023
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Treating bacterial infections with bacteriophages in the 21st century.Southern African journal of infectious diseases · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Angela MakumiDepartment of Animal and Human Health, International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi 00100, Kenya.ORCID 0000-0003-3510-972X
Amos Lucky MhoneDepartment of Animal and Human Health, International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi 00100, Kenya.
Josiah OdabaDepartment of Animal and Human Health, International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi 00100, Kenya.
Linda GuantaiDepartment of Animal and Human Health, International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi 00100, Kenya.
Nicholas SvitekDepartment of Animal and Human Health, International Livestock Research Institute (ILRI), P.O. Box 30709, Nairobi 00100, Kenya.ORCID 0000-0002-4539-5806

Funding

Consortium of International Agricultural Research Centers [CRP 3.7]International Development Research Centre 109049UKAID Global AMR Innovation 109049
6 · The paper itself

Abstract

One of the world's fastest-growing human populations is in Sub-Saharan Africa (SSA), accounting for more than 950 million people, which is approximately 13% of the global population. Livestock farming is vital to SSA as a source of food supply, employment, and income. With this population increase, meeting this demand and the choice for a greater income and dietary options come at a cost and lead to the spread of zoonotic diseases to humans. To control these diseases, farmers have opted to rely heavily on antibiotics more often to prevent disease than for treatment. The constant use of antibiotics causes a selective pressure to build resistant bacteria resulting in the emergence and spread of multi-drug resistant (MDR) organisms in the environment. This necessitates the use of alternatives such as bacteriophages in curbing zoonotic pathogens. This review covers the underlying problems of antibiotic use and resistance associated with livestock farming in SSA, bacteriophages as a suitable alternative, what attributes contribute to making bacteriophages potentially valuable for SSA and recent research on bacteriophages in Africa. Furthermore, other topics discussed include the creation of phage biobanks and the challenges facing this kind of advancement, and the regulatory aspects of phage development in SSA with a focus on Kenya.

Indexed as

antimicrobial resistance (AMR)bacteriophage therapymulti-drug resistance (MDR)regulations of phage productsSub-Saharan Africa (SSA)

Identifiers

PMID34572667
PMCPMC8470919

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.