Evidence map›Paper›PMID 34572635›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi-Latest Findings.

Estefanía Butassi, Laura Svetaz, María Cecilia Carpinella, Thomas Efferth, Susana Zacchino

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Understanding the Effect of Propolis and Its Derivatives AgainstJournal of fungi (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. TargetingInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Microorganisms · 2022
    Article
  17. Frontiers in cellular and infection microbiology · 2022
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Estefanía ButassiPharmacognosy Area, School of Biochemical and Pharmaceutical Sciences, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, Argentina.
Laura SvetazPharmacognosy Area, School of Biochemical and Pharmaceutical Sciences, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, Argentina.
María Cecilia CarpinellaFine Chemical and Natural Products Laboratory, IRNASUS CONICET-UCC, Universidad Católica de Córdoba, Córdoba 5016, Argentina.
Thomas EfferthInstitute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Susana ZacchinoPharmacognosy Area, School of Biochemical and Pharmaceutical Sciences, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, Argentina.
National University of Rosario · ARJohannes Gutenberg University Mainz · DEUniversidad Católica de Córdoba · AR

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT 2017-1381Agencia Nacional de Promoción Científica y Tecnológica PICT 2018-02034Agencia Nacional de Promoción Científica y Tecnológica PICT 2019-00721
6 · The paper itself

Abstract

The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017-May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty-seven manuscripts evaluated

Indexed as

antifungal resistanceCandida spp.Cryptococcus spp.filamentous fungifungal biofilmFusarium spp.mechanisms of antibiofilm actionnatural products

Identifiers

PMID34572635
PMCPMC8471798
OpenAlexW3197673937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.