Evidence map›Paper›PMID 34572627›Full record

ArticleAntibiotics (Basel, Switzerland)2021

In Vitro Activity of Propolis on Oral Microorganisms and Biofilms.

Alexandra Stähli, Hannah Schröter, Simonetta Bullitta, Francesca Serralutzu, Antonio Dore, Sandor Nietzsche, Egle Milia, Anton Sculean, Sigrun Eick

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Understanding the Effect of Propolis and Its Derivatives AgainstJournal of fungi (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Herbal medicines to prevent dental caries.The Cochrane database of systematic reviews · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Antimicrobial Efficiency ofMicroorganisms · 2023
    Review
  13. Case of Mixed Infection of Toenail Caused byJournal of fungi (Basel, Switzerland) · 2023
    Article
  14. Article
  15. The Effects of Propolis on Viral Respiratory Diseases.Molecules (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Alexandra StähliDepartment of Periodontology, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland.
Hannah SchröterDepartment of Periodontology, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland.
Simonetta BullittaC.N.R., Institute for Animal Production System in Mediterranean Environment (ISPAAM), Traversa La Crucca 3, Località Baldinca, 07100 Sassari, Italy.
Francesca SerralutzuC.N.R., Institute for Animal Production System in Mediterranean Environment (ISPAAM), Traversa La Crucca 3, Località Baldinca, 07100 Sassari, Italy.
Antonio DoreC.N.R., Institute of Sciences of Food Production (ISPA), Traversa La Crucca 3, Località Baldinca, 07100 Sassari, Italy.
Sandor NietzscheCenter for Electron Microscopy, Jena University Hospital, 07743 Jena, Germany.
Egle MiliaDepartment of Medicine, Surgery and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-4272-0538
Anton SculeanDepartment of Periodontology, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-2836-5477
Sigrun EickDepartment of Periodontology, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-4619-2461
University of Bern · CHIstituto per il Sistema Produzione Animale in Ambiente Mediterraneo · ITInstitute of Sciences of Food Production · ITJena University Hospital · DEUniversity of Sassari · IT

Funding

Association for Dental Infection Control, Chéserex, Switzerland. no number
6 · The paper itself

Abstract

Natural products are being discussed as alternatives to commonly used chemicals in antimicrobial therapy. The study aimed to investigate the antimicrobial activity of propolis against microbial species associated with caries, periodontal disease, and Candida infections. Two commercially available ethanolic extracts of Brazilian and one of European propolis (EEP) were used. The minimal inhibitory concentrations (MIC) of propolis and controls against eight microbial strains were determined. Scanning and transmission electron microscopy (SEM and TEM) images visualized the effect of propolis on microorganisms. Subsequently, the activity on three different multi-species biofilms (both formation and existing biofilms) was assessed. All MIC values of the Brazilian EEPs were low against the tested oral species (≤0.1 mg/mL-3.13 mg/mL propolis (

Indexed as

candidiasiscariesminimal inhibitory concentrationsoral multi-species biofilmperiodontal diseasepropolis preparations

Identifiers

PMID34572627
PMCPMC8472590
OpenAlexW3193658210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.