Evidence map›Paper›PMID 34572621›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Sars-Cov-2 Infection in Patients on Long-Term Treatment with Macrolides in Spain: A National Cross-Sectional Study.

Carmen Marina Meseguer Barros, Natalia Alzueta Isturiz, Rita Sainz de Rozas Aparicio, Rafael Aguilella Vizcaíno, Laura López Esteban, Sonia Anaya Ordóñez, Itxasne Lekue Alkorta, Salvadora Martín Suances, Jorge Ignacio Jiménez Arce, Maite Fernández Vicente and 47 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors at 17 institutions in 2 countries.

Carmen Marina Meseguer BarrosService of Pharmacy, Ouest Primary Health Care Area, Madrid Health Service, Madrid C/Alonso Canonum 8, 28933 Madrid, Spain.ORCID 0000-0002-9603-2298
Natalia Alzueta IsturizUnit of Drug Assessment, Advice and Research, Navarra Health Service, Pamplona, Plaza de la Paz s/n, 31002 Pamplona, Spain.ORCID 0000-0002-8513-239X
Rita Sainz de Rozas AparicioService of Pharmacy, Cruces University Hospital, Osakidetza, Barakaldo, Vizcaya, Plaza Cruces s/n, 48903 Barakaldo, Spain.
Rafael Aguilella VizcaínoService of Pharmacy, North Primary Health Care Area, Madrid Health Service, Madrid C/Alfonso Rodriguez Castelao 17, 28034 Madrid, Spain.
Laura López EstebanService of Pharmacy, Center Primary Health Care Area, Madrid Health Service, Madrid C/Alberto López Palacios, 28021 Madrid, Spain.
Sonia Anaya OrdóñezService of Pharmacy, Granada Metropolitano Primary Health Care Area, Andalusian Health Service, Complejo Administrativo Almanjayar C/Joaquina Eguaras nº 2, Edificio 2 Planta 1, 18013 Granada, Spain.
Itxasne Lekue AlkortaPrimary Care Pharmacy Service, Integrated Health Organization, Barakaldo-Sestao, Osakidetza, Avenida Antonio Miranda 5, 48902 Barakaldo, Spain.
Salvadora Martín SuancesService of Pharmacy, Granada Metropolitano Primary Health Care Area, Andalusian Health Service, Complejo Administrativo Almanjayar C/Joaquina Eguaras nº 2, Edificio 2 Planta 1, 18013 Granada, Spain.
Jorge Ignacio Jiménez ArceClinical Unit Primary Care Pharmacy Area VII Asturias, Principado de Asturias Health Service, Pza. Sindicatos Mineros num 3, 33600 Mieres, Spain.
Maite Fernández VicenteService of Pharmacy, Burgos Primary Health Care, Castilla y León Health, Burgos, Castilla y León, C/Calle José María de la Puente, 09006 Burgos, Spain.
Yolanda Borrego IzquierdoCantabria Primary Care Management, Cantabrian Health Service, C/Vargas nº 57 7 planta, 39010 Santander, Spain.
Raquel Prieto SánchezCantabria Primary Care Management, Cantabrian Health Service, C/Vargas nº 57 7 planta, 39010 Santander, Spain.
Silvia Casado CasusoCantabria Primary Care Management, Cantabrian Health Service, C/Vargas nº 57 7 planta, 39010 Santander, Spain.
Rosa MadridejosService of Pharmacy, Mutua Terrasa, Barcelona, CAP Sant Cugat, C/de la Mina s/n, 08173 Sant Cugat del Vallès, Spain.ORCID 0000-0002-2640-6872
Carmen Marquina VerdeService of Pharmacy, Burgos Primary Health Care, Castilla y León Health, Burgos, Castilla y León, C/Calle José María de la Puente, 09006 Burgos, Spain.
Rosa Tomás SanzService of Pharmacy, Mutua Terrasa, Barcelona, CAP Sant Cugat, C/de la Mina s/n, 08173 Sant Cugat del Vallès, Spain.
María Oro FernándezPrimary Care Pharmacy and Residential Social Centers, Cantabrian Health Service, Santander, Cantabria, Av Herrera Oria s/n, 39011 Santander, Spain.
Sara Gallardo BorgeService of Pharmacy, Mutua Terrasa, Barcelona, CAP Sant Cugat, C/de la Mina s/n, 08173 Sant Cugat del Vallès, Spain.
Eva Lázaro LópezClinical Unit Primary Care Pharmacy Area, Area VIII-Asturias, Principado de Asturias Health, Asturias, C/Manuel Suarez s/n, 33930 Langreo, Spain.
María Belén Pina GadeaService of Primary Care Pharmacy, Zaragoza II Sector, Aragón Health Service, Zaragoza, C/Condes de Aragón 30, 50009 Zaragoza, Spain.
Mercedes Pereira PíaSan Roque Health Center, Lugo Health Area, Cervo Monforte, Rúa Peña Anda 1, 27002 Lugo, Spain.
María Victoria Maestre-SánchezCondado-Campiña Health District, La Palma del Condado, C/Ronda de los Legionarios 8, 21700 Huelva, Spain.
Esther Ribes-MurilloUnit of Pharmacy, Lerida Primary Care Direction, Lerida Territorial Management, Catalan Institute of Health, Lerida, Cataluña, Avenida de Blondel 23, 25002 Lleida, Spain.
Constanza Gómez de OñaClinical Unit Primary Care Pharmacy Area V, Asturias, Principado de Asturias Health Service, Gijón, Asturias C/Severo Ochoa s/n, 33208 Gijón, Spain.
Álvarez María Jesús LallanaService of Primary Care Pharmacy, Zaragoza II Sector, Aragón Health Service, Zaragoza, C/Condes de Aragón 30, 50009 Zaragoza, Spain.ORCID 0000-0002-3803-5298
Concepción Celaya LeceaPharmacy Sub-Directorate, Navarre Health Service, Pamplona, Plaza de la Paz s/n, Planta 4, 31002 Pamplona, Spain.
María Ana Prado PrietoService of Pharmacy, Valladolid Primary Health Care, Castilla y Leon Health, Valladolid, Castilla y León, Cardenal Torquemada nº 54, 47010 Valladolid, Spain.ORCID 0000-0003-3617-3934
Aranzazu Aranguez RuizMérida Health Area Management, Merida Hospital, Badajoz, Extremadura, Av. Don Antonio Campos Hoyos 26, 06800 Mérida, Spain.
Vicente Olmo QuintanaService of Pharmacy, Gran Canaria Health Area, Canary Islands Health Service, C/Luis Doreste Silva 34-40, Canary Islands Health Service, 35004 Las Palmas de Gran Canaria, Spain.
Noemí Villén RomeroPrimary Care Barcelona City, Catalan Institute of Health, Barcelona, C/Manso 19, 1ª Planta, 08015 Barcelona, Spain.
Carolina Payá GinerHealth Management Area Campo de Gibraltar Pharmacy Unit, Pharmaceutical Primary Care, Carretera Getares, s/n, 11207 Algeciras, Spain.
Angeles Lloret CallejoPrimary Care Management, Integrated Care Management Albacete-University Hospital Complex, Castilla-La Mancha Health Service, Albacete, Castilla La Mancha, C/Hermanos Falcó 37, 02006 Albacete, Spain.
Alvaro Fernández FerreiroDirectorate of Health Care and Evaluation, Principado de Asturias Health Service, Oviedo, Asturias, Pza del Carbayón 1, 33001 Oviedo, Spain.
Blanca Basagoiti CarreñoPharmacy Unit, Northwest Primary Health Care Area, Madrid Health Service, Madrid, Avda. De España 7, 28220 Majadahonda, Spain.ORCID 0000-0002-6292-5207
Ana Aurelia Iglesias IglesiasPharmacy Service, Regional Hospital of Manacor, Balearic Islands Health Service, Inca, Balearic Islands, Carretera Manacor-Alcudia, s/n, 07500 Manacor, Spain.
Antonio Martín AlonsoPharmacy Unit, Northwest Primary Health Care Area, Madrid Health Service, Madrid, Avda. De España 7, 28220 Majadahonda, Spain.
Ana Díez AlcántaraPharmacy Unit, Northwest Primary Health Care Area, Madrid Health Service, Madrid, Avda. De España 7, 28220 Majadahonda, Spain.
Esther Marco TejónCuenca Primary Care Management, Hospital Virgen de la Luz, Castilla La Mancha Health Service, C/Hermandad de Donantes de Sangre 1, 16002 Cuenca, Spain.
Marta Lestón VázquezPrimary Care Barcelona City, Catalan Institute of Health, Barcelona, C/Manso 19, 1ª Planta, 08015 Barcelona, Spain.
Mª Ángeles Ariza CopadoPharmacy Unit, Management of Urgencies and Health Emergencies, Murcia, C/Escultor José Sánchez Lozano Nº 7, 2ª planta, 30005 Murcia, Spain.
Marta Aparicio CuevaPharmaceutical Health Area, Health Department Alicante, Valencia C/Pintor Baeza 12, (Edificio gris) 7ª planta, 03010 Alicante, Spain.
Belén Escudero VilaplanaService of Pharmacy, Ouest Primary Health Care Area, Madrid Health Service, Madrid C/Alonso Canonum 8, 28933 Madrid, Spain.
Marisa NiciezaPrincipado de Asturias Health Service Pharmacy Coordination, Central Services, Principado de Asturias Health Service, Asturias, Pza Carbayón 1, 33001 Oviedo, Spain.
Gracia Picazo SanchizService of Pharmacy, Ouest Primary Health Care Area, Madrid Health Service, Madrid C/Alonso Canonum 8, 28933 Madrid, Spain.
Genma María Silva RiádigosService of Pharmacy, Ouest Primary Health Care Area, Madrid Health Service, Madrid C/Alonso Canonum 8, 28933 Madrid, Spain.
Lucía Jamart SánchezService of Pharmacy, Ouest Primary Health Care Area, Madrid Health Service, Madrid C/Alonso Canonum 8, 28933 Madrid, Spain.
Ángel García ÁlvarezPharmacy Service, Tramuntana Sector, Inca Regional Hospital, Balearic Islands Health Service, Balearic Islands, Carretera Vella de Llubí, s/n, 07300 Inca, Spain.
Antonio García BonillaPharmacy Unit, Jerez, Northwest Coast and Sierra de Cádiz Primary Health Care Area, Jerez de la Frontera, Cádiz, C/José Luis Diez nº 14, 11402 Jerez de la Frontera, Spain.
Rafael Herrero DelicadoPharmaceutical Management Service, General Directorate of Health Assistance, Murciano Health Service, Murcia Edificio Habitamia I C/Central, 7-3ª Planta, 30100 Espinardo, Spain.
Virginia Arroyo PinedaTalavera de la Reina Primary Care Management, Nuestra Señora del Prado Hospital, Castilla-La Mancha Health Service, Cuenca, Ctra. Madrid-Extremadura, Km 114, 45600 Toledo, Spain.
Belén de la HijaTalavera de la Reina Primary Care Management, Nuestra Señora del Prado Hospital, Castilla-La Mancha Health Service, Cuenca, Ctra. Madrid-Extremadura, Km 114, 45600 Toledo, Spain.
Amelia Troncoso MariñoPrimary Care Barcelona City, Catalan Institute of Health, Barcelona, C/Manso 19, 1ª Planta, 08015 Barcelona, Spain.
Isabel Tofiño GonzálezTalavera de la Reina Primary Care Management, Nuestra Señora del Prado Hospital, Castilla-La Mancha Health Service, Cuenca, Ctra. Madrid-Extremadura, Km 114, 45600 Toledo, Spain.ORCID 0000-0003-1375-7128
Mónica Susana Mateu GarcíaPharmacy Service, Vinarós Department of Health, Castellón, Comunidad Valenciana, Av/Gil de Atrocillo s/n, 12500 Vinaròs, Spain.
Pablo García VázquezBierzo Health care Management, El Bierzo Hospital, Castilla y León Health Service, C/Médicos sin Frontera, 7, 24404 Ponferrada, Spain.
Joaquín Pérez MartínFaculty of Social Sciences, Area of Design, Gaming and Multimedia, Madrid, Calle Tajo s/n, 28670 Villaviciosa de Odón, Spain.
Rocío Fernández-UrrusunoService of Pharmacy, Aljarafe-Sevilla Norte Primary Health Care Area, Avda de las Américas s/n, 41927 Mairena del Aljarafe, Spain.ORCID 0000-0002-6261-6869
Madrid Health Service · ESGobierno del Principado de Asturias · ESServicio Cántabro de Salud · ESHospital General Nuestra Señora del Prado · ESUniversity Hospital Mútua de Terrassa · ESAndalusian Health Service · ESOsakidetza · ESServicio Aragonés de Salud · ESTechnological Institute of Castilla y León · ESFundación Hospital Manacor · ESGibraltar Health Authority · GIHospital Comarcal de Inca · ESHospital El Bierzo · ESHospital Jerez Puerta del Sur · ESHospital Virgen de la Luz · ESInstituto de Arqueología-Mérida · ESUniversidad de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to know the prevalence and severity of COVID-19 in patients treated with long-term macrolides and to describe the factors associated with worse outcomes. A cross-sectional study was conducted in Primary Care setting. Patients with macrolides dispensed continuously from 1 October 2019 to 31 March 2020, were considered. Main outcome: diagnosis of coronavirus disease-19 (COVID-19). Secondary outcomes: symptoms, severity, characteristics of patients, comorbidities, concomitant treatments. A total of 3057 patients met the inclusion criteria. Median age: 73 (64-81) years; 55% were men; 62% smokers/ex-smokers; 56% obese/overweight. Overall, 95% of patients had chronic respiratory diseases and four comorbidities as a median. Prevalence of COVID-19: 4.8%. This was in accordance with official data during the first wave of the pandemic. The most common symptoms were respiratory: shortness of breath, cough, and pneumonia. Additionally, 53% percent of patients had mild/moderate symptoms, 28% required hospital admission, and 19% died with COVID-19. The percentage of patients hospitalized and deaths were 2.6 and 5.8 times higher, respectively, in the COVID-19 group (

Indexed as

ambulatory careazithromycinCOVID-19long-term treatmentmacrolidesoutpatientsSARS-CoV-2

Identifiers

PMID34572621
PMCPMC8468207
OpenAlexW3195276720

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.