Evidence map›Paper›PMID 34572595›Full record

ArticleBiomolecules2021

Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells.

Pinki Nandi, Chloe E Jang, Kyle Biggar, Chidambra D Halari, Thomas Jansson, Madhulika B Gupta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Pinki NandiDepartments of Pediatrics, University of Western Ontario, London, ON N6A 5C1, Canada.
Chloe E JangDepartment of Biochemistry, University of Western Ontario, London, ON N6A 5C1, Canada.
Kyle BiggarInstitute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Chidambra D HalariDepartments of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 3K7, Canada.
Thomas JanssonDepartment of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Madhulika B GuptaDepartments of Pediatrics, University of Western Ontario, London, ON N6A 5C1, Canada.
Western University · CACarleton University · CAChildren’s Health Research Institute · CAUniversity of Colorado Anschutz Medical Campus · US

Funding

Decidual nutrient sensing and IGFBP-1 phosphorylation in placental insufficiencyR01HD089980 · NICHD · UNIVERSITY OF COLORADO DENVER · PI GUPTA, MADHULIKA, JANSSON, THOMAS · 2017 to 2021
$1.4M
NICHD NIH HHS R01 HD089980NIH HHS R01HD089980
6 · The paper itself

Abstract

Insulin-like growth factor-1 (IGF-1) bioavailability in pregnancy is governed by IGF binding protein (IGFBP-1) and its phosphorylation, which enhances the affinity of IGFBP-1 for the growth factor. The decidua is the predominant source of maternal IGFBP-1; however, the mechanisms regulating decidual IGFBP-1 secretion/phosphorylation are poorly understood. Using decidualized primary human endometrial stromal cells (HESCs) from first-trimester placenta, we tested the hypothesis that mTORC1 signaling mechanistically links hypoxia to decidual IGFBP-1 secretion/phosphorylation. Hypoxia inhibited mechanistic target of rapamycin (mTORC1) (p-P70-S6K/Thr389, -47%,

Indexed as

Signal TransductionAdultCasein Kinase IICell HypoxiaCells, CulturedCell ShapeDeciduaFemaleGene SilencingHumansInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor IMechanistic Target of Rapamycin Complex 1PhosphorylationPregnancyPregnancy Trimester, FirstCasein Kinase IIIGF1R protein, humanInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor IMechanistic Target of Rapamycin Complex 1Protein Kinase CReceptor, IGF Type 1RNA, Small InterferingTSC2 protein, humanTuberous Sclerosis Complex 2 Proteinfetal developmenthumansIGF Type 1insulin-like growth factor Iplacental insufficiencyreceptor

Identifiers

PMID34572595
PMCPMC8471256
OpenAlexW3200612659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.