Evidence map›Paper›PMID 34572594›Full record

ArticleBiomolecules2021

The Effects of Fibrinogen's Interactions with Its Neuronal Receptors, Intercellular Adhesion Molecule-1 and Cellular Prion Protein.

Nurul Sulimai, Jason Brown, David Lominadze

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nurul SulimaiDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Jason BrownDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
David LominadzeDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-9911-4539
University of South Florida · US

Funding

Mechanisms of neurodegeneration by a fibrinogen-containing protein complex during traumatic brain injuryR01HL146832 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LOMINADZE, DAVID · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL146832NIH HHS HL146832
6 · The paper itself

Abstract

Neuroinflammatory diseases, such as Alzheimer's disease (AD) and traumatic brain injury (TBI), are associated with the extravascular deposition of the fibrinogen (Fg) derivative fibrin and are accompanied with memory impairment. We found that during the hyperfibrinogenemia that typically occurs during AD and TBI, extravasated Fg was associated with amyloid beta and astrocytic cellular prion protein (PrP

Indexed as

AnimalsCell DeathFibrinogenIntercellular Adhesion Molecule-1Interleukin-6MiceMice, Inbred C57BLMitochondriaNeuronsNitritesOxidative StressPrion ProteinsReactive Oxygen SpeciesReceptors, Cell SurfaceSuperoxidesUp-RegulationFibrinogenIntercellular Adhesion Molecule-1Interleukin-6NitritesPrion ProteinsReactive Oxygen SpeciesReceptors, Cell SurfaceSuperoxidesmitochondrial activationneuronal deathnitriteproinflammatory cytokineproximity ligationROS

Identifiers

PMID34572594
PMCPMC8464854
OpenAlexW3201503042

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.