Evidence map›Paper›PMID 34572579›Full record

ArticleBiomolecules2021

Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M

Bathini Thissera, Ahmed M Sayed, Marwa H A Hassan, Sayed F Abdelwahab, Ngozi Amaeze, Valeria T Semler, Faizah N Alenezi, Mohammed Yaseen, Hani A Alhadrami, Lassaad Belbahri and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Bioactive Phytochemicals ofAntioxidants (Basel, Switzerland) · 2022
    Article
  6. Article
  7. Bioactive natural products in COVID-19 therapy.Frontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bathini ThisseraSchool of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.ORCID 0000-0002-0998-4187
Ahmed M SayedDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.ORCID 0000-0002-1442-183X
Marwa H A HassanDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.ORCID 0000-0002-0952-5984
Sayed F AbdelwahabDepartment of Pharmaceutics and Industrial Pharmacy, Taif College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-9636-7485
Ngozi AmaezeSchool of Health and Life Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.
Valeria T SemlerSchool of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.ORCID 0000-0001-9559-0821
Faizah N AleneziThe Public Authority for Applied Education and Training, Adailiyah 00965, Kuwait.
Mohammed YaseenSchool of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.ORCID 0000-0002-2460-1893
Hani A AlhadramiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80402, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-4822-1895
Lassaad BelbahriLaboratory of Soil Biology, University of Neuchatel, 2000 Neuchatel, Switzerland.ORCID 0000-0001-7040-4500
Mostafa E RatebSchool of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.ORCID 0000-0003-4043-2687

Funding

Taif University Researchers Supporting Project TURSP-2020/51
6 · The paper itself

Abstract

SARS-CoV-2 virus mutations might increase its virulence, and thus the severity and duration of the ongoing pandemic. Global drug discovery campaigns have successfully developed several vaccines to reduce the number of infections by the virus. However, finding a small molecule pharmaceutical that is effective in inhibiting SARS-CoV-2 remains a challenge. Natural products are the origin of many currently used pharmaceuticals and, for this reason, a library of in-house fungal extracts were screened to assess their potential to inhibit the main viral protease M

Indexed as

Coronavirus 3C ProteasesCysteine Proteinase InhibitorsMolecular Docking SimulationMolecular Dynamics SimulationBenzodiazepinonesPenicilliumSARS-CoV-2BenzodiazepinonesCoronavirus 3C ProteasescyclopeninCysteine Proteinase Inhibitorscyclopenindockingmolecular dynamic simulationsMproPenicillium citrinumSARS-CoV-2

Identifiers

PMID34572579
PMCPMC8467212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.