ArticleBiomolecules2021
Computational Analysis of Naturally Occurring Aristolochic Acid Analogues and Their Biological Sources.
Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- NPBS Atlas: a comprehensive data resource for exploring the biological sources of natural products.Journal of cheminformatics · 2025Article
- Trends in the incidence of urothelial carcinoma in Taiwan after the ban on aristolochic acid-containing Chinese herbal preparations, 2001-2018: a national population-based cohort study.Journal of cancer research and clinical oncology · 2023Article
- Uptake, Translocation, and Fate of Carcinogenic Aristolochic Acid in Typical Vegetables in Soil-Plant Systems.Molecules (Basel, Switzerland) · 2022Article
- Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced NephrotoxicityInternational journal of biological sciences · 2022Article
- Immunomodulatory Potential of the IndustrializedFoods (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors.
Funding
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Abstract
Aristolochic acids are known for nephrotoxicity, and implicated in multiple cancer types such as hepatocellular carcinomas demonstrated by recent studies. Natural products that are analogues to aristolochic acids have been constantly isolated from organisms; a larger chemical space of these compounds and a wider coverage of biological sources should be determined in consideration of the potential hazard of aristolochic acid analogues and the wide distribution of their biological sources in the nature. Therefore, we carried out an in silico research of naturally occurring aristolochic acid analogues and their biological sources, as a supplement to existing studies. The result shows a chemical space of 238 naturally occurring aristolochic acid analogues that are present in 175 species of biological sources including 44 traditional medicines. With the computational estimation for toxicity and the implication in hazard assessment of a biological source with the presence of aristolochic acid analogues, we propose that additional awareness should be raised to the public for avoidance of toxic species, especially those that are used as herbal medicines and easily accessible.
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