ArticleBiomolecules2021
The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles.
Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Nanofiber based transformative approaches for tendon regenerative engineering: past, present and future.Nanomedicine (London, England) · 2026Review
- Electrospun Amorphous Solid Dispersions with Lopinavir and Ritonavir for Improved Solubility and Dissolution Rate.Nanomaterials (Basel, Switzerland) · 2024Article
- Review
- Comparison of the mechanical characteristics of produced nanofibers by electrospinning process based on different collectors.Heliyon · 2024Article
- Core-Sheath Pt-CeONanomaterials (Basel, Switzerland) · 2023Article
- Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers.Biomolecules · 2022Review
- The Key Elements for Biomolecules to Biomaterials and to Bioapplications.Biomolecules · 2022Article
- Electrospun Core-Sheath Nanofibers with Variable Shell Thickness for Modifying Curcumin Release to Achieve a Better Antibacterial Performance.Biomolecules · 2022Article
- A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing.Biomolecules · 2022Review
- Electrospun Medical Sutures for Wound Healing: A Review.Polymers · 2022Review
- Electrospun Nanofiber Membranes for Air Filtration: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Formulation Development and Evaluation of Pravastatin-Loaded Nanogel for Hyperlipidemia Management.Gels (Basel, Switzerland) · 2022Article
- Article
- Review
- Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers' Architecture.Pharmaceutics · 2022Review
- Astragalus Polysaccharides/PVA Nanofiber Membranes Containing Astragaloside IV-Loaded Liposomes and Their Potential Use for Wound Healing.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release.Polymers · 2021Article
- Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium.Membranes · 2021Article
- Electrospun Medicated Nanofibers for Wound Healing: Review.Membranes · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug-metformin hydrochloride (MET). The core-sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process-nanostructure-performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core-sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.
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Registered trials
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