Evidence map›Paper›PMID 34572500›Full record

ArticleBiomolecules2021

Blood-Derived α-Synuclein Aggregated in the Substantia Nigra of Parabiotic Mice.

Xizhen Ma, Leilei Chen, Ning Song, Le Qu, Jun Wang, Junxia Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xizhen MaShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Leilei ChenShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Ning SongShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Le QuShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Jun WangShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Junxia XieShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a pathological biomarker of Parkinson's disease, α-synuclein is thought to be a prion-like protein, but evidence for the transmission of α-synuclein from blood to the brain is unclear. The goals of this study were to determine whether blood-derived α-synuclein could enter the brains of mice and whether α-synuclein in the brain could be cleared by parabiosis. Heterochronic parabiosis was performed on

Indexed as

Protein Aggregatesalpha-SynucleinAnimalsFeasibility StudiesMice, TransgenicParabiosisSubstantia Nigraalpha-SynucleinProtein AggregatesA53Talpha-synucleinparabiosisParkinson’s diseasetransmission

Identifiers

PMID34572500
PMCPMC8471402
OpenAlexW3197541624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.