Evidence map›Paper›PMID 34572498›Full record

ArticleBiomolecules2021

Design and Synthesis of Novel Peptides to Protect Ferulic Acid against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin.

Yinghan Wu, Hisham N Farrag, Tamaki Kato, Hua Li, Shinya Ikeno

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Glycation Inhibition of Bovine Serum Albumin by Extracts ofAvicenna journal of medical biotechnology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yinghan WuSchool of Food Science and Engineering, Yangzhou University, 196 Huayang West Road, Yangzhou 225127, China.
Hisham N FarragDepartment of Biological Functions Engineering, Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Kitakyushu Science and Research Park, Kitakyushu 8080196, Fukuoka, Japan.
Tamaki KatoDepartment of Biological Functions Engineering, Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Kitakyushu Science and Research Park, Kitakyushu 8080196, Fukuoka, Japan.
Hua LiSchool of Food Science and Engineering, Yangzhou University, 196 Huayang West Road, Yangzhou 225127, China.
Shinya IkenoDepartment of Biological Functions Engineering, Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Kitakyushu Science and Research Park, Kitakyushu 8080196, Fukuoka, Japan.ORCID 0000-0003-2937-4025
Kyushu Institute of Technology · JPYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferulic acid (FA) is known for its excellent antioxidant properties, which can provide many health benefits. One of its drawbacks is its instability under UVA light, which limits its potency. In this study, the new peptides LW2 (QNKRFYFRKNQ) and CW2 (a cyclic form of LW2) were designed based on bovine serum albumin site IIA conformation. A UVA irradiation experiment was performed to investigate the protective ability of these peptides towards FA against UVA damage. The percentages of FA remaining under UV irradiation due to the protection of CW2 and LW2 were 83% and 76%, respectively. The results showed the importance of the cationic residues and hydrophobic residues included in the peptide sequences. Moreover, the cyclic rigid structure showed greater protective ability as compared to its linear counterpart.

Indexed as

Drug DesignUltraviolet RaysAmino Acid SequenceCoumaric AcidsPeptidesProtein DomainsSerum Albumin, BovineSpectrophotometry, UltravioletTime FactorsCoumaric Acidsferulic acidPeptidesSerum Albumin, Bovinebovine serum albumincyclic peptideferulic acidUVA light

Identifiers

PMID34572498
PMCPMC8472342
OpenAlexW3198581031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.