Evidence map›Paper›PMID 34572445›Full record

ArticleBiomedicines2021

Master Regulators of Epithelial-Mesenchymal Transition and WNT Signaling Pathways in Juvenile Nasopharyngeal Angiofibromas.

Naiade Calanca, Sara Martoreli Silveira Binato, Sabrina Daniela da Silva, Helena Paula Brentani, Luiz Ubirajara Sennes, Clóvis Antonio Lopes Pinto, Maria Aparecida Custódio Domingues, Carlos Eduardo Fonseca-Alves, Claudia Aparecida Rainho, Silvia Regina Rogatto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Burns & trauma · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Naiade CalancaDepartment of Chemical and Biological Sciences, Institute of Biosciences, São Paulo State University (UNESP), Botucatu 18618-689, Brazil.ORCID 0000-0003-2681-0987
Sara Martoreli Silveira BinatoInternational Research Center, CIPE, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Sabrina Daniela da SilvaDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC H3A 1A1, Canada.
Helena Paula BrentaniDepartment of Psychiatry, LIM23 (FMUSP), University of São Paulo (USP), São Paulo 05403-010, Brazil.
Luiz Ubirajara SennesDepartment of Otorhinolaryngology, LIM23 (FMUSP), University of São Paulo (USP), São Paulo 05403-010, Brazil.
Clóvis Antonio Lopes PintoDepartment of Pathology, A.C. Camargo Cancer Center, São Paulo 01509-010, Brazil.
Maria Aparecida Custódio DominguesDepartment of Pathology, Faculty of Medicine, São Paulo State University (UNESP), Botucatu 18618-687, Brazil.
Carlos Eduardo Fonseca-AlvesInstitute of Health Sciences, Paulista University-UNIP, Bauru 17048-290, Brazil.ORCID 0000-0002-6702-6139
Claudia Aparecida RainhoDepartment of Chemical and Biological Sciences, Institute of Biosciences, São Paulo State University (UNESP), Botucatu 18618-689, Brazil.ORCID 0000-0002-0285-1162
Silvia Regina RogattoDepartment of Clinical Genetics, University Hospital of Southern Denmark, 7100 Vejle, Denmark.ORCID 0000-0003-4637-5687
Universidade Estadual Paulista (Unesp) · BRAC Camargo Hospital · BRUniversidade de São Paulo · BRJewish General Hospital · CAUniversidade Paulista · BRUniversity of Southern Denmark · DK

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 06/52074-4Research Council of Lillebaelt Hospital - Efond, Region of Southern Denmark, DK J.nr. 20/14277
6 · The paper itself

Abstract

Juvenile nasopharyngeal angiofibroma (JNA) is a rare fibrovascular benign tumor showing an invasive growth pattern and affecting mainly male adolescents. We investigated the role of epithelial-mesenchymal transition (EMT) and WNT signaling pathways in JNA. Gene expression profiles using nine JNA paired with four inferior nasal turbinate samples were interrogated using a customized 2.3K microarray platform containing genes mainly involved in EMT and WNT/PI3K pathways. The expression of selected genes (

Indexed as

epithelial–mesenchymal transitiongene expression profilejuvenile nasopharyngeal angiofibromatumor microenvironmenttumor signaling pathwaysWNT pathway

Identifiers

PMID34572445
PMCPMC8469518
OpenAlexW3199886014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.