Evidence map›Paper›PMID 34572327›Full record

ArticleBiomedicines2021

Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Na

Chiung-Wei Huang, Pi-Chen Lin, Jian-Lin Chen, Ming-Jen Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Pharmacological therapy of non-dystrophic myotonias.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2025
    Review
  3. Review
  4. Cannabidiol Modulates M-Type KBiomedicines · 2023
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Chiung-Wei HuangDepartment of Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0001-8276-4538
Pi-Chen LinDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Jian-Lin ChenDepartment of Physiology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.ORCID 0000-0003-3966-0658
Ming-Jen LeeDepartment of Neurology, National Taiwan University Hospital, Taipei 100233, Taiwan.
Kaohsiung Medical University · TWNational Taiwan University · TWNational Taiwan University Hospital · TW

Funding

Kaohsiung Medical University KMU-Q107007Kaohsiung Medical University KMU-Q108004Kaohsiung Medical University Hospital KMUH106-M608Ministry of Science and Technology, Taiwan 109-2314-B-002-121-MY3Ministry of Science and Technology, Taiwan MOST 107-2320-B-037-004Ministry of Science and Technology, Taiwan MOST 108-2320-B-037-032Ministry of Science and Technology, Taiwan MOST 109-2320-B-037-009Ministry of Science and Technology, Taiwan MOST 110-2320-B-037-004
6 · The paper itself

Abstract

Cannabidiol (CBD), one of the cannabinoids from the cannabis plant, can relieve the myotonia resulting from sodium channelopathy, which manifests as repetitive discharges of muscle membrane. We investigated the binding kinetics of CBD to Na

Indexed as

cannabidiolfast inactivationmyotoniaNav1.4 channelslow-inactivation

Identifiers

PMID34572327
PMCPMC8465134
OpenAlexW3197151365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.