Evidence map›Paper›PMID 34572295›Full record

ArticleBiomedicines2021

Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin.

Hsien-Lin Chen, Yu-Chieh Su, Huang-Chi Chen, Jui-Hsin Su, Chang-Yi Wu, Shih-Wei Wang, In-Pin Lin, Chung-Yi Chen, Chien-Hsing Lee

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Nitrobenzoate-Derived Compound X8 Impairs Vascular Development in Zebrafish.International journal of molecular sciences · 2022
    Article
  4. The power of heteronemin in cancers.Journal of biomedical science · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Hsien-Lin ChenDivision of General Surgery, Department of Surgery, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Yu-Chieh SuDepartment of Medicine, School of Medicine, I-Shou University, Kaohsiung 840203, Taiwan.
Huang-Chi ChenDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 81267, Taiwan.
Jui-Hsin SuNational Museum of Marine Biology & Aquarium, Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94401, Taiwan.
Chang-Yi WuDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Shih-Wei WangDepartment of Medicine, Mackay Medical College, New Taipei City 252005, Taiwan.ORCID 0000-0001-7522-6352
In-Pin LinDepartment of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chung-Yi ChenDepartment of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung 83102, Taiwan.ORCID 0000-0002-7026-3944
Chien-Hsing LeeDepartment of Pharmacology, School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-0576-7150
Kaohsiung Medical University · TWE-Da Hospital · TWFooyin University · TWNational Dong Hwa University · TWNational Sun Yat-sen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphatic metastasis is a biological procedure associated with the pathogenesis of several diseases, especially in tumor metastasis. Therefore, regulation of lymphangiogenesis has become a promising strategy for cancer therapy. In this study, we aimed to investigate the anti-lymphangiogenic effect of heteronemin (SP-1) isolated from the sponge

Indexed as

ARF-1endothelial-to-mesenchymal transitionheteroneminlymphangiogenesisMMP-9/VE-cadherin/vimentinzebrafish

Identifiers

PMID34572295
PMCPMC8471334
OpenAlexW3198237241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.