ArticleChildren (Basel, Switzerland)2021
The Challenges of Measuring and Valuing Quality of Life in Preschool Children: A Retrospective Review of NICE Appraisals.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Conservative versus liberal oxygenation targets in critically ill children: the Oxy-PICU RCT.Health technology assessment (Winchester, England) · 2026Trial
- Measuring health-related quality of life in infants and toddlers: conceptual challenges and proposed recommendations.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Impact of inactivated influenza vaccination on health-related quality of life for young children using Japanese experimental EuroQol toddler and infant populations (EQ-TIPS) v2.0.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Valuing health states for infants and toddlers: challenges and methodological considerations in EQ-TIPS preference elicitation.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Developing the EuroQol toddler and infant populations (EQ-TIPS) instrument: qualitative analysis of expert views on content validity and conceptual challenges.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Exploring valuation of a modified EQ-5D-Y-3L adapted for 2-4 year olds: a think-aloud study.Health and quality of life outcomes · 2025Article
- Determining health-related quality of life among children with malaria in Kenya: does the choice of EQ-5D value set matter?Health and quality of life outcomes · 2025Article
- Measuring and Valuing Health Using EuroQol Instruments: New Developments 2025 and Beyond.Applied health economics and health policy · 2025Review
- A scoping review of challenges in pediatric health technology assessments with a focus on pharmaceutical interventions.International journal of technology assessment in health care · 2025Article
- Do the Age of Children and Parental Status Matter in Valuing the Child Health Utility 9D (CHU9D)?PharmacoEconomics · 2025Article
- Performance of the Experimental EuroQol Toddler and Infant Populations (EQ-TIPS) and PedsQL in Infants and Toddlers with a Health Condition.Journal of health economics and outcomes research · 2025Article
- EuroQol Toddler and Infant Populations (EQ-TIPS): Age-Related Differences in Performance.Children (Basel, Switzerland) · 2024Article
- Meeting the Challenges of Preference-Weighted Health-Related Quality-of-Life Measurement in Children.PharmacoEconomics · 2024Article
- Psychometric Performance Comparison of the Adapted versus Original Versions of the EQ-5D-Y-3L and -Y-5L in Proxy Respondents for 2- to 4-Year-Olds.PharmacoEconomics · 2024Article
- A comparison of the Child Health Utility 9D and the Health Utilities Index for estimating health utilities in pediatric inflammatory bowel disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Health Utilities of Bilateral Severe-to-Profound Hearing Loss with Assistive Devices.Healthcare (Basel, Switzerland) · 2023Article
- Access to novel drugs and therapeutics for children and youth: Eliciting citizens' values to inform public funding decisions.Health expectations : an international journal of public participation in health care and health policy · 2023Article
- EQ-5D-Y-3L Value Sets, Valuation Methods and Conceptual Questions.PharmacoEconomics · 2022Article
- Capturing what matters: updating NICE methods guidance on measuring and valuing health.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Review
- Exploring Health-Related Quality of Life Burden in Peanut Allergy and the Potential Benefit of Oral Immunotherapy: Estimation of Health State Utility Values for Children and Adolescents and Their Caregivers.Patient preference and adherence · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health technology assessment agencies evaluate interventions across the lifespan. However, there is no consensus about best-practice methods to measure health-related quality of life (HRQoL) in preschool children (<5 years) and data are often scarce. We reviewed methods used to capture the HRQoL of preschool children in past National Institute for Health and Care Excellence (NICE) appraisals to establish whether there is a need for better methods in this area and if so, to identify priority research areas. We identified past NICE appraisals that included preschool children, examining the methods used to generate utility values and whether committees believed these captured HRQoL adequately. Of the 12 appraisals, most used generic HRQoL measures designed for adults. Measures were usually completed by adult patients or clinical experts. Committees frequently commented on limitations in the HRQoL data. While acknowledging that data collection may be challenging, committees would value evidence based on HRQoL data from parents or guardians collected as part of a clinical trial. We identified several research priorities including the psychometric properties of existing measures; the feasibility and validity of valuation studies; and mapping. Progress in these areas will help ensure that the aspects of HRQoL which matter to children and their families are captured in NICE evaluations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.