Evidence map›Paper›PMID 34572128›Full record

ArticleCells2021

Exercise and Sestrin Mediate Speed and Lysosomal Activity in

Alyson Sujkowski, Robert Wessells

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025
    Review
  2. Review
  3. Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. The mTOR signaling pathway in cardiac aging.The journal of cardiovascular aging · 2023
    Article
  6. Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alyson SujkowskiDepartment of Physiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-9909-9279
Robert WessellsDepartment of Physiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Wayne State University · US

Funding

Octpamine controls adaptation to endurance exercise in DrosophilaR01AG059683 · NIA · WAYNE STATE UNIVERSITY · PI Robert John Wessells · 2018 to 2026
$3.0M
NIA NIH HHS R01 AG059683NIH HHS 1RO1AG059683
6 · The paper itself

Abstract

Chronic exercise is widely recognized as an important contributor to healthspan in humans and in diverse animal models. Recently, we have demonstrated that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, are critical mediators of exercise benefits in flies and mice. Knockout of Sestrins prevents exercise adaptations to endurance and flight in

Indexed as

Adaptation, PhysiologicalLocomotionPhysical Conditioning, AnimalAnimalsBiomechanical PhenomenaDrosophilaDrosophila ProteinsLysosomesMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2OxidoreductasesPositive Transcriptional Elongation Factor BProto-Oncogene Proteins c-aktSestrinsDrosophila ProteinsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Oxidoreductasespgc protein, DrosophilaPositive Transcriptional Elongation Factor BProto-Oncogene Proteins c-aktsesn protein, DrosophilaSestrinsDrosophilaexerciseSestrin

Identifiers

PMID34572128
PMCPMC8466685
OpenAlexW3200240077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.