Evidence map›Paper›PMID 34572101›Full record

ArticleCells2021

Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles.

Hong Gao, Zhenlong Luo, Zhongmou Jin, Yudong Ji, Wei Ying

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Hong GaoDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA 92093, USA.
Zhenlong LuoDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA 92093, USA.
Zhongmou JinDivision of Biological Sciences, University of California, San Diego, CA 92093, USA.
Yudong JiDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA 92093, USA.
Wei YingDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-4890-7256
University of California San Diego · USUnion Hospital · CN

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Mechanisms by which hepatocyte extracellular miRNAs mediate peripheral insulin sensitivityR01DK125560 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YING, WEI · 2021 to 2025
$2.0M
Adipose tissue macrophages secrete exosome-miRs as paracrine/endocrine molecules to directly modulate insulin target cell function in response to obesityR00DK115998 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YING, WEI · 2020 to 2022
$739k
Natural Science Foundation of Jilin Province 81900786NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R00 DK115998NIDDK NIH HHS R00DK115998NIDDK NIH HHS R01 DK125560NIDDK NIH HHS R01DK125560
6 · The paper itself

Abstract

Obesity induces an adaptive expansion of β cell mass and insulin secretion abnormality. Expansion of adipose tissue macrophages (ATMs) is a hallmark of obesity. Here, we assessed a novel role of ATMs in mediating obesity-induced β cell adaptation through the release of miRNA-containing extracellular vesicles (EVs). In both in vivo and in vitro experiments, we show that ATM EVs derived from obese mice notably suppress insulin secretion and enhance β cell proliferation. We also observed similar phenotypes from human islets after obese ATM EV treatment. Importantly, depletion of miRNAs blunts the effects of obese ATM EVs, as evidenced by minimal effects of obese DicerKO ATM EVs on β cell responses. miR-155 is a highly enriched miRNA within obese ATM EVs and miR-155 overexpressed in β cells impairs insulin secretion and enhances β cell proliferation. In contrast, knockout of miR-155 attenuates the regulation of obese ATM EVs on β cell responses. We further demonstrate that the miR-155-

Indexed as

Adaptation, PhysiologicalAdipose TissueAnimalsCell ProliferationExtracellular VesiclesGlucoseInsulin-Secreting CellsInsulin SecretionMacrophagesMaleMiceMice, Inbred C57BLMice, ObeseMicroRNAsObesitySweetening AgentsGlucoseMicroRNAsSweetening Agentsadipose tissue macrophageextracellular vesicleinsulin secretionmiRNAobesityβ cell replication

Identifiers

PMID34572101
PMCPMC8472266
OpenAlexW3199482711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.