Evidence map›Paper›PMID 34572064›Full record

ArticleCells2021

Porin 1 Modulates Autophagy in Yeast.

Filomena Broeskamp, Elizabeth S M Edrich, Oskar Knittelfelder, Lisa Neuhaus, Thorsten Meyer, Jonas Heyden, Lukas Habernig, Florian Kreppel, Campbell W Gourlay, Patrick Rockenfeller

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Filomena BroeskampChair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), University of Witten/Herdecke (UW/H), Stockumer Str. 10, 58453 Witten, Germany.ORCID 0000-0002-6955-3901
Elizabeth S M EdrichKent Fungal Group, School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Oskar KnittelfelderMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.ORCID 0000-0002-1565-7238
Lisa NeuhausChair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), University of Witten/Herdecke (UW/H), Stockumer Str. 10, 58453 Witten, Germany.
Thorsten MeyerChair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), University of Witten/Herdecke (UW/H), Stockumer Str. 10, 58453 Witten, Germany.
Jonas HeydenChair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), University of Witten/Herdecke (UW/H), Stockumer Str. 10, 58453 Witten, Germany.ORCID 0000-0002-5914-3159
Lukas HabernigDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.
Florian KreppelChair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), University of Witten/Herdecke (UW/H), Stockumer Str. 10, 58453 Witten, Germany.
Campbell W GourlayKent Fungal Group, School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.ORCID 0000-0002-2373-6788
Patrick RockenfellerChair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), University of Witten/Herdecke (UW/H), Stockumer Str. 10, 58453 Witten, Germany.
Witten/Herdecke University · DEUniversity of Kent · GBMax Planck Institute of Molecular Cell Biology and Genetics · DEStockholm University · SE

Funding

Austrian Science Fund J3742-B28Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen 311-8.03.03.02-142461
6 · The paper itself

Abstract

Autophagy is a cellular recycling program which efficiently reduces the cellular burden of ageing. Autophagy is characterised by nucleation of isolation membranes, which grow in size and further expand to form autophagosomes, engulfing cellular material to be degraded by fusion with lysosomes (vacuole in yeast). Autophagosomal membranes do not bud from a single cell organelle, but are generated de novo. Several lipid sources for autophagosomal membranes have been identified, but the whole process of their generation is complex and not entirely understood. In this study, we investigated how the mitochondrial outer membrane protein porin 1 (Por1), the yeast orthologue of mammalian voltage-dependent anion channel (VDAC), affects autophagy in yeast. We show that

Indexed as

AutophagyAutophagosomesCarboxy-LyasesMitochondriaMitochondrial ProteinsPhosphatidylethanolaminesPorinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCarboxy-LyasesMitochondrial ProteinsphosphatidylethanolaminePhosphatidylethanolaminesPor1 protein, S cerevisiaePorinsPsd1 protein, S cerevisiaeSaccharomyces cerevisiae Proteinsautophagyphosphatidylethanolaminephosphatidylserine decarboxylasevoltage dependent anion channel (VDAC)

Identifiers

PMID34572064
PMCPMC8464718
OpenAlexW3200016138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.