Evidence map›Paper›PMID 34572057›Full record

ReviewCells2021

Role of ERLINs in the Control of Cell Fate through Lipid Rafts.

Valeria Manganelli, Agostina Longo, Vincenzo Mattei, Serena Recalchi, Gloria Riitano, Daniela Caissutti, Antonella Capozzi, Maurizio Sorice, Roberta Misasi, Tina Garofalo

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  5. Review
  6. A New GlyT2 Variant Associated with Hyperekplexia.International journal of molecular sciences · 2025
    Article
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  8. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Valeria ManganelliDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Agostina LongoDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Vincenzo MatteiBiomedicine and Advanced Technologies Rieti Center, "Sabina Universitas", 02100 Rieti, Italy.ORCID 0000-0003-4677-088X
Serena RecalchiDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Gloria RiitanoDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Daniela CaissuttiDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Antonella CapozziDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Maurizio SoriceDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Roberta MisasiDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Tina GarofaloDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-0645-2510
Sapienza University of Rome · ITIMT School for Advanced Studies Lucca · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 2017 FS5SHL to MS; PRIN 2017 SNRXH3 to RM
6 · The paper itself

Abstract

ER lipid raft-associated protein 1 (ERLIN1) and 2 (ERLIN2) are 40 kDa transmembrane glycoproteins belonging to the family of prohibitins, containing a PHB domain. They are generally localized in the endoplasmic reticulum (ER), where ERLIN1 forms a heteroligomeric complex with its closely related ERLIN2. Well-defined functions of ERLINS are promotion of ER-associated protein degradation, mediation of inositol 1,4,5-trisphosphate (IP

Indexed as

Calcium SignalingLipid MetabolismApoptosisAutophagyEndoplasmic ReticulumHumansMembrane MicrodomainsMitochondrial MembranesNerve Tissue ProteinsProhibitinsERLIN1 protein, humanNerve Tissue ProteinsPHB protein, humanProhibitinsapoptosisautophagyERLINslipid raftsMAMs

Identifiers

PMID34572057
PMCPMC8470593
OpenAlexW3201206728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.