Evidence map›Paper›PMID 34572055›Full record

ReviewCells2021

Ultrastructural Features of Membranous Replication Organelles Induced by Positive-Stranded RNA Viruses.

Van Nguyen-Dinh, Eva Herker

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. AnThe Journal of general virology · 2026
    Article
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  4. Proviral insights of glycolytic enolase inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Van Nguyen-DinhInstitute of Virology, Philipps-University Marburg, 35043 Marburg, Germany.
Eva HerkerInstitute of Virology, Philipps-University Marburg, 35043 Marburg, Germany.ORCID 0000-0001-9644-2484
Philipps University of Marburg · DE

Funding

Deutsche Forschungsgemeinschaft HE 6889/2, HE 6889/5LOEWE Center DRUID (Novel Drug Targets against Poverty-related and Neglected Tropical Infectious Diseases) Herker
6 · The paper itself

Abstract

All intracellular pathogens critically depend on host cell organelles and metabolites for successful infection and replication. One hallmark of positive-strand RNA viruses is to induce alterations of the (endo)membrane system in order to shield their double-stranded RNA replication intermediates from detection by the host cell's surveillance systems. This spatial seclusion also allows for accruing host and viral factors and building blocks required for efficient replication of the genome and prevents access of antiviral effectors. Even though the principle is iterated by almost all positive-strand RNA viruses infecting plants and animals, the specific structure and the organellar source of membranes differs. Here, we discuss the characteristic ultrastructural features of the virus-induced membranous replication organelles in plant and animal cells and the scientific progress gained by advanced microscopy methods.

Indexed as

Host-Pathogen InteractionsVirus ReplicationAnimalsIntracellular MembranesOrganellesPlantsPositive-Strand RNA VirusesRNA, ViralRNA Virus InfectionsRNA, Viralelectron microscopymembrane alterationspositive-strand RNA virusesreplication organelleviral replication complex

Identifiers

PMID34572055
PMCPMC8464962
OpenAlexW3199740316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.