Evidence map›Paper›PMID 34571997›Full record

ArticleCells2021

Perturbed Brain Glucose Metabolism Caused by Absent SIRT3 Activity.

Tibor Kristian, Arman J Karimi, Adam Fearnow, Jaylyn Waddell, Mary C McKenna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. The role of SIRT3 in homeostasis and cellular health.Frontiers in cellular neuroscience · 2024
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tibor KristianVeterans Affairs Maryland Health Center System, 10 North Greene Street, Baltimore, MD 21201, USA.
Arman J KarimiDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
Adam FearnowVeterans Affairs Maryland Health Center System, 10 North Greene Street, Baltimore, MD 21201, USA.
Jaylyn WaddellDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
Mary C McKennaDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USVA Maryland Health Care System · US

Funding

Project IV- Cerebellar Function After Hypoxia-Ischemia and Precipitating InflammationP01HD085928 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI BEARER, CYNTHIA FRANCES, MCCARTHY, MARGARET M. · 2016 to 2020
$6.3M
Using NAD+ precursor for treatment of global cerebral ischemiaR01NS119275 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KRISTIAN, TIBOR · 2021 to 2025
$1.9M
The role of nicotinamide mononucleotide dependent mitochondrial reactive oxygen species generation in acute brain injuryI01BX004895 · VA · BALTIMORE VA MEDICAL CENTER · PI KRISTIAN, TIBOR · 2020 to 2024
–
BLRD VA I01 BX004895NICHD NIH HHS P01 HD085928NINDS NIH HHS R01 NS119275U.S. Department of Veterans Affairs BX004895
6 · The paper itself

Abstract

Acetylation is a post-translational modification that regulates the activity of enzymes fundamentally involved in cellular and mitochondrial bioenergetic metabolism. NAD

Indexed as

AcetylationAnimalsAstrocytesBrainCarbohydrate MetabolismEnergy MetabolismFemaleGlucoseGlutamic AcidGlutamineMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaNeuronsGlucoseGlutamic AcidGlutamineNeurotransmitter AgentsSirt3 protein, mouseSirtuin 313C-NMR spectroscopy[1,6-13C]glucoseacetylationknock out mousemetabolismmitochondriaNAD+SIRT3

Identifiers

PMID34571997
PMCPMC8469836
OpenAlexW3196298775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.