Evidence map›Paper›PMID 34571977›Full record

ReviewCells2021

Advances in ER-Phagy and Its Diseases Relevance.

Lingang He, Xuehong Qian, Yixian Cui

Abstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Visualizing ER-phagy and ER architecture in vivo.The Journal of cell biology · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Membrane Contact Sites in Proteostasis and ER Stress Response.Contact (Thousand Oaks (Ventura County, Calif.))
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lingang HeDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China.ORCID 0000-0002-5621-314X
Xuehong QianDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China.ORCID 0000-0002-1685-9499
Yixian CuiDepartment of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-8260-1421

Funding

National Natural Science Foundation of China 32070744The start fund from Wuhan University 413100036
6 · The paper itself

Abstract

As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases.

Indexed as

AnimalsAutophagyEndoplasmic ReticulumEndoplasmic Reticulum StressHomeostasisHumansIntracellular MembranescancerER-phagymetabolic diseasesneurodegenerative diseasesreceptor

Identifiers

PMID34571977
PMCPMC8465915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.