Evidence map›Paper›PMID 34571950›Full record

ArticleCells2021

Nogo-A Modulates the Synaptic Excitation of Hippocampal Neurons in a Ca

Kristin Metzdorf, Steffen Fricke, Maria Teresa Balia, Martin Korte, Marta Zagrebelsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kristin MetzdorfDivision of Cellular Neurobiology, Zoological Institute, TU Braunschweig, D-38106 Braunschweig, Germany.
Steffen FrickeDivision of Cell Physiology, Zoological Institute, TU Braunschweig, D-38106 Braunschweig, Germany.
Maria Teresa BaliaDivision of Cellular Neurobiology, Zoological Institute, TU Braunschweig, D-38106 Braunschweig, Germany.ORCID 0000-0002-0803-6644
Martin KorteDivision of Cellular Neurobiology, Zoological Institute, TU Braunschweig, D-38106 Braunschweig, Germany.ORCID 0000-0001-6956-5913
Marta ZagrebelskyDivision of Cellular Neurobiology, Zoological Institute, TU Braunschweig, D-38106 Braunschweig, Germany.
Technische Universität Braunschweig · DEHelmholtz Centre for Infection Research · DE

Funding

Deutsche Forschungsgemeinschaft ZA 554/3-2
6 · The paper itself

Abstract

A tight regulation of the balance between inhibitory and excitatory synaptic transmission is a prerequisite for synaptic plasticity in neuronal networks. In this context, the neurite growth inhibitor membrane protein Nogo-A modulates synaptic plasticity, strength, and neurotransmitter receptor dynamics. However, the molecular mechanisms underlying these actions are unknown. We show that Nogo-A loss-of-function in primary mouse hippocampal cultures by application of a function-blocking antibody leads to higher excitation following a decrease in GABA

Indexed as

AnimalsCalciumExcitatory Postsynaptic PotentialsFemaleHippocampusMaleMiceMice, Inbred C57BLNeuronal PlasticityNeuronsNogo ProteinsReceptors, AMPASynapsesSynaptic TransmissionCalciumNogo ProteinsReceptors, AMPAcalcium-permeable (CP-) AMPARsexcitation/inhibition (E/I) balancehippocampusimmediate early genes (IEGs)Nogo-Asynaptic plasticitysynaptic transmission

Identifiers

PMID34571950
PMCPMC8467072
OpenAlexW3198881572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.