Evidence map›Paper›PMID 34571854›Full record

ArticleCells2021

PAX7 Balances the Cell Cycle Progression via Regulating Expression of

Anita Florkowska, Igor Meszka, Joanna Nowacka, Monika Granica, Zuzanna Jablonska, Magdalena Zawada, Lukasz Truszkowski, Maria A Ciemerych, Iwona Grabowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anita FlorkowskaDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0002-2536-9520
Igor MeszkaDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0003-3314-5348
Joanna NowackaDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
Monika GranicaDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0001-8782-7139
Zuzanna JablonskaDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
Magdalena ZawadaDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
Lukasz TruszkowskiDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0001-7816-6092
Maria A CiemerychDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
Iwona GrabowskaDepartment of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0001-6455-9434
University of Warsaw · PL

Funding

Ministerstwo Nauki i Szkolnictwa Wyższego DSM #501-D114-86-0115000-15Narodowe Centrum Nauki 2016/23/N/NZ4/01746Narodowe Centrum Nauki N N303548139
6 · The paper itself

Abstract

PAX7 transcription factor plays a crucial role in embryonic myogenesis and in adult muscles in which it secures proper function of satellite cells, including regulation of their self renewal. PAX7 downregulation is necessary for the myogenic differentiation of satellite cells induced after muscle damage, what is prerequisite step for regeneration. Using differentiating pluripotent stem cells we documented that the absence of functional PAX7 facilitates proliferation. Such action is executed by the modulation of the expression of two proteins involved in the DNA methylation, i.e.,

Indexed as

AnimalsAPOBEC DeaminasesCell CycleCell Cycle ProteinsCell DifferentiationCell ProliferationCells, CulturedDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3BFemaleGene ExpressionGene Expression Regulation, DevelopmentalMaleMiceMice, Inbred C57BLApobec2 protein, mouseAPOBEC DeaminasesCell Cycle ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BMuscle ProteinsPax7 protein, mousePAX7 Transcription Factor5azaCcell cycledifferentiationESCsiPSCsmousemyogenesisPax7skeletal musclestem cellsteratoma

Identifiers

PMID34571854
PMCPMC8472244
OpenAlexW3194995210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.