Evidence map›Paper›PMID 34571850›Full record

ArticleCells2021

Metavariables Resuming Host Immune Features and Nodal Involvement Are Associated with Oncological Outcomes in Oral Cavity Squamous Cell Carcinoma.

Francesco Missale, Mattia Bugatti, Davide Mattavelli, Silvia Lonardi, Davide Lombardi, Piero Nicolai, Cesare Piazza, Simonetta Battocchio, Anna Maria Bozzola, Stefano Calza and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Inducing immunogenic cell death in immuno-oncological therapies.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Francesco MissaleDepartment of Molecular and Translational Medicine, University of Brescia, 25125 Brescia, Italy.ORCID 0000-0002-5357-5348
Mattia BugattiUnit of Pathology, ASST Spedali Civili di Brescia, 25100 Brescia, Italy.
Davide MattavelliUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-7023-6746
Silvia LonardiUnit of Pathology, ASST Spedali Civili di Brescia, 25100 Brescia, Italy.
Davide LombardiUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-8430-4789
Piero NicolaiSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Via Giustiniani, 2-35128 Padua, Italy.
Cesare PiazzaUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, Italy.
Simonetta BattocchioUnit of Pathology, ASST Spedali Civili di Brescia, 25100 Brescia, Italy.
Anna Maria BozzolaUnit of Pathology, ASST Spedali Civili di Brescia, 25100 Brescia, Italy.
Stefano CalzaUnit of Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, 25125 Brescia, Italy.ORCID 0000-0003-4996-7995
William VermiDepartment of Molecular and Translational Medicine, University of Brescia, 25125 Brescia, Italy.ORCID 0000-0002-2291-2997
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Brescia · ITThe Netherlands Cancer Institute · NLUniversity of Padua · ITWashington University in St. Louis · US

Funding

Associazione Italiana per la Ricerca sul Cancro AIRC-IG-23179
6 · The paper itself

Abstract

Oral cavity squamous cell carcinoma (OSCC) is a common head and neck cancer characterized by a poor prognosis associated with locoregional or distant failure. Among the predictors of prognosis, a dense infiltration of adaptive immune cells is protective and associated with improved clinical outcomes. However, few tools are available to integrate immune contexture variables into clinical settings. By using digital microscopy analysis of a large retrospective OSCC cohort (n = 182), we explored the clinical significance of tumor-infiltrating CD8

Indexed as

Adaptive ImmunityAgedBiomarkers, TumorCarcinoma, Squamous CellCD8-Positive T-LymphocytesCohort StudiesFemaleHead and Neck NeoplasmsHumansItalyLymphocytes, Tumor-InfiltratingMaleMiddle AgedMouth NeoplasmsNeoplasm Recurrence, LocalPrognosisBiomarkers, TumorbiomarkerCD8data reductionhead and necklymphocyteoral neoplasmsPCAperipheralsurvival modelingTIL

Identifiers

PMID34571850
PMCPMC8472482
OpenAlexW3197192934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.