Evidence map›Paper›PMID 34571839›Full record

ArticleCells2021

Redox-Sensitive and Folate-Receptor-Mediated Targeting of Cervical Cancer Cells for Photodynamic Therapy Using Nanophotosensitizers Composed of Chlorin e6-Conjugated β-Cyclodextrin via Diselenide Linkage.

Howard Kim, Mi Woon Kim, Young-Il Jeong, Hoe Saeng Yang

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Howard KimDepartment of Medicine, Graduate School, Dongguk University, Gyeongju 38067, Korea.ORCID 0000-0002-1123-9485
Mi Woon KimDepartment of Anesthesiology and Pain Medicine, College of Medicine, Dongguk University, Gyeongju 38067, Korea.
Young-Il JeongResearch Institute of Convergence of Biomedical Sciences, Pusan National University Yangsan Hospital, Gyeongnam 50612, Korea.
Hoe Saeng YangDepartment of Obstetrics and Gynecology, Dongguk University College of Medicine, Gyeongju 38067, Korea.ORCID 0000-0003-3874-5799
Dongguk University · KRChosun University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to fabricate a reactive oxygen species (ROS)-sensitive and folate-receptor-targeted nanophotosensitizer for the efficient photodynamic therapy (PDT) of cervical carcinoma cells. Chlorin e6 (Ce6) as a model photosensitizer was conjugated with succinyl β-cyclodextrin via selenocystamine linkages. Folic acid (FA)-poly(ethylene glycol) (PEG) (FA-PEG) conjugates were attached to these conjugates and then FA-PEG-succinyl β-cyclodextrin-selenocystamine-Ce6 (FAPEGbCDseseCe6) conjugates were synthesized. Nanophotosensitizers of FaPEGbCDseseCe6 conjugates were fabricated using dialysis membrane. Nanophotosensitizers showed spherical shapes with small particle sizes. They were disintegrated in the presence of hydrogen peroxide (H

Indexed as

Animalsbeta-CyclodextrinsCell LineCell Line, TumorChlorophyllidesFemaleFolate Receptors, GPI-AnchoredFolic AcidHeLa CellsHumansMiceMice, Inbred BALB CMice, NudeNanoparticlesOxidation-ReductionParticle Sizebeta-CyclodextrinsChlorophyllidesFolate Receptors, GPI-AnchoredFolic AcidPhotosensitizing AgentsphytochlorinPorphyrinscervical cancerfolate receptornanophotosensitizerphotodynamic therapyROS-sensitive

Identifiers

PMID34571839
PMCPMC8465130
OpenAlexW3193694384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.