Evidence map›Paper›PMID 34571730›Full record

ArticleBiology2021

An Alignment-Independent Approach for the Study of Viral Sequence Diversity at Any Given Rank of Taxonomy Lineage.

Li Chuin Chong, Wei Lun Lim, Kenneth Hon Kim Ban, Asif M Khan

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Li Chuin ChongCentre for Bioinformatics, School of Data Sciences, Perdana University, Kuala Lumpur 50490, Malaysia.ORCID 0000-0002-3574-1365
Wei Lun LimFaculty of Computing and Informatics, Multimedia University, Cyberjaya 63100, Malaysia.ORCID 0000-0002-0301-2846
Kenneth Hon Kim BanDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
Asif M KhanCentre for Bioinformatics, School of Data Sciences, Perdana University, Kuala Lumpur 50490, Malaysia.ORCID 0000-0001-9202-279X
Bezmiâlem Vakıf Üniversitesi · TRMultimedia University · MYNational University of Singapore · SGPerdana University · MY

Funding

Malaysian Medical Association MMA/2019/PUSDS/MAK/011The Scientific and Technological Research Council of Turkey (TÜBİTAK) the 2232 International Fellowship for Outstanding Researchers Program of TÜBİTAK (Project No: 118C314)
6 · The paper itself

Abstract

The study of viral diversity is imperative in understanding sequence change and its implications for intervention strategies. The widely used alignment-dependent approaches to study viral diversity are limited in their utility as sequence dissimilarity increases, particularly when expanded to the genus or higher ranks of viral species lineage. Herein, we present an alignment-independent algorithm, implemented as a tool, UNIQmin, to determine the effective viral sequence diversity at any rank of the viral taxonomy lineage. This is done by performing an exhaustive search to generate the minimal set of sequences for a given viral non-redundant sequence dataset. The minimal set is comprised of the smallest possible number of unique sequences required to capture the diversity inherent in the complete set of overlapping

Indexed as

alignment-freealignment independentminimal setproteomesequence diversityUNIQminvirus

Identifiers

PMID34571730
PMCPMC8466476
OpenAlexW3196725191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.