Observational studyClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022
High Prevalence of Osteopathy in Chronic Pancreatitis: A Cross-sectional Analysis From the PROCEED Study.
Observational study in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03099850 (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies - PROCEED Study), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies - PROCEED Study
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Burden of bone disease in chronic pancreatitis: A systematic review and meta-analysis.World journal of gastroenterology · 2023Pooled it
- Etiology, diagnosis, and management of chronic pancreatitis associated primary complications: a narrative review.Frontiers in medicine · 2026Review
- Burden of Metabolic Bone Disease in Patients with Immunoglobulin G4-Related Disease With and Without Autoimmune Pancreatitis: A Cross-Sectional Study.Clinical and translational gastroenterology · 2025Article
- Coupled Bone-Muscle Degeneration in Chronic Pancreatitis: A Juvenile Porcine Model of Secondary Osteosarcopenia.International journal of molecular sciences · 2025Article
- Healthcare disparities in pancreatitis: knowledge gaps and next steps.Current opinion in gastroenterology · 2024Review
- Management of chronic pancreatitis: recent advances and future prospects.Therapeutic advances in gastroenterology · 2024Review
- Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023Article
- Bone Loss in Patients with Pancreatic Neuroendocrine Tumors.Journal of clinical medicine · 2022Article
- A Pilot Study to Assess Opportunistic Use of CT-Scan for Osteoporosis Screening in Chronic Pancreatitis.Frontiers in physiology · 2022Article
- [Chronic Pancreatitis: A Review of Its Most Relevant Aspects].Acta gastroenterologica LatinoamericanaReview
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsChronic pancreatitis (CP) is associated with osteopathy (osteoporosis or osteopenia). However, existing literature is mostly limited to retrospective or administrative studies that have not clearly defined the prevalence and risk factors. Our aim was to identify patient- and disease-related associations with osteopathy in a prospective cohort study of CP.
methodsWe studied 282 subjects with definitive CP enrolled in the PROCEED study who had a baseline dual-energy X-ray absorptiometry (DXA) scan. Osteopenia and osteoporosis were defined using the lowest T-scores. Clinical data were collected using standardized case report forms. Comparisons were performed with a multivariate logistic regression model with forward selection to identify risk factors for osteopathy.
resultsThe majority of subjects had osteopathy on DXA scan (56.0%; 17.0% osteoporosis; 39.0% osteopenia). Subjects with osteopathy had a higher prevalence of traumatic (40.0% vs 26.4%; P = .02) and spontaneous fractures (3.9% vs 0; P = .04). On multivariate analysis, older age (odds ratio [OR], 1.29 per 5 years; 95% confidence interval [CI], 1.15-1.45), female sex (OR, 3.08; 95% CI, 1.75-5.43), white race (OR, 2.68; 95% CI, 1.20-6.01), and underweight body mass index category (OR, 7.40; 95% CI, 1.56-34.99) were associated with higher probability of osteopathy. There were no significant associations between osteopathy and other patient and disease-related features of CP.
conclusionIn the largest study of patients with CP who underwent DXA screening, the majority had osteopathy. There are overlapping risk factors with osteopathy in the general population, but the high prevalence in men and younger women supports the need for future investigations into the mechanisms of bone loss in CP. CLINICALTRIALS: gov number, NCT03099850.
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