ArticleNeuroImage2021
A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- White matter lesions disrupt cholinergic pathways important for cognition in Parkinson's disease.Brain : a journal of neurology · 2026Article
- Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- MindGrab: A spectrally-motivated architecture for accessible deep learning in neuroimaging.NeuroImage · 2026Article
- Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- A hypothalamic-brainstem activity sequence underlies arousal fluctuations during daytime drowsiness.bioRxiv : the preprint server for biology · 2026Article
- Cholinergic Basal Forebrain Atrophy Accelerates Cognitive Decline via Cortical Thinning: The Moderating Role of Amyloid-β Pathology in Preclinical Alzheimer's Disease.Research square · 2026Article
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy.Movement disorders clinical practice · 2026Article
- Subcortical correlates of sleep in aging and Alzheimer's disease: anBrain communications · 2026Article
- Inter- and intra-individual differences in brain sex map to neuroendocrine profiles.bioRxiv : the preprint server for biology · 2025Article
- Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025Article
- Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health.Communications biology · 2025Article
- Automated Segmentation of the Pituitary and Pineal Glands.Human brain mapping · 2025Article
- Fast segmentation with the NextBrain histological atlas.bioRxiv : the preprint server for biology · 2025Article
- Advanced brain aging, selective vulnerability in gray matter, and cognition in Parkinson's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Electroconvulsive therapy-specific volume changes in nuclei of the amygdala and their relationship to long-term anxiety improvement in depression.Molecular psychiatry · 2025Observational
- Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [Neurobiology of aging · 2025Article
- Skull stripping tools in pediatric T2-weighted MRI scans: a retrospective evaluation of segmentation performance.Frontiers in neuroscience · 2025Article
- Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers.Frontiers in aging neuroscience · 2025Article
- Exploring the association between childhood trauma and limbic system subregion volumes in healthy individuals: a neuroimaging study.BMC psychiatry · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
A tool was developed to automatically segment several subcortical limbic structures (nucleus accumbens, basal forebrain, septal nuclei, hypothalamus without mammillary bodies, the mammillary bodies, and fornix) using only a T1-weighted MRI as input. This tool fills an unmet need as there are few, if any, publicly available tools to segment these clinically relevant structures. A U-Net with spatial, intensity, contrast, and noise augmentation was trained using 39 manually labeled MRI data sets. In general, the Dice scores, true positive rates, false discovery rates, and manual-automatic volume correlation were very good relative to comparable tools for other structures. A diverse data set of 698 subjects were segmented using the tool; evaluation of the resulting labelings showed that the tool failed in less than 1% of cases. Test-retest reliability of the tool was excellent. The automatically segmented volume of all structures except mammillary bodies showed effectiveness at detecting either clinical AD effects, age effects, or both. This tool will be publicly released with FreeSurfer (surfer.nmr.mgh.harvard.edu/fswiki/ScLimbic). Together with the other cortical and subcortical limbic segmentations, this tool will allow FreeSurfer to provide a comprehensive view of the limbic system in an automated way.
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