Evidence map›Paper›PMID 34571092›Full record

ArticleUrology2022

Effect of Metabolic Syndrome on Anatomy and Function of the Lower Urinary Tract Assessed on MRI.

Alex P Tannenbaum, Matthew D Grimes, Christopher L Brace, Cody J Johnson, Samuel D Koebe, Lucille E Anzia, Lu Mao, William A Ricke, Diego Hernando, Alejandro Roldan-Alzate and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alex P TannenbaumUniversity of Wisconsin School of Medicine and Public Heath, Madison, WI.
Matthew D GrimesDepartment of Urology, University of Wisconsin, Madison, WI.
Christopher L BraceDepartment of Radiology, University of Wisconsin, Madison, WI; Department of Biomedical Engineering, University of Wisconsin, Madison, WI.
Cody J JohnsonDepartment of Radiology, University of Wisconsin, Madison, WI; Department of Mechanical Engineering, University of Wisconsin, Madison, WI.
Samuel D KoebeUniversity of Wisconsin School of Medicine and Public Heath, Madison, WI.
Lucille E AnziaCollege of Medicine, University of Central Florida, Orlando, FL.
Lu MaoDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI.
William A RickeDepartment of Urology, University of Wisconsin, Madison, WI; George M. O'Brien Center of Research Excellence, University of Wisconsin, Madison, WI.
Diego HernandoDepartment of Radiology, University of Wisconsin, Madison, WI; Department of Medical Physics, University of Wisconsin, Madison, WI.
Alejandro Roldan-AlzateDepartment of Radiology, University of Wisconsin, Madison, WI; Department of Mechanical Engineering, University of Wisconsin, Madison, WI.
Shane A WellsDepartment of Radiology, University of Wisconsin, Madison, WI. Electronic address: sawells@wisc.edu.
University of Wisconsin–Madison · USUniversity of Wisconsin System · USUniversity of Central Florida · US

Funding

Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2014 to 2023
$12.8M
Wisconsin Multidisciplinary K12 Urologic Research Career Development ProgramK12DK100022 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI CHAD M. VEZINA · 2013 to 2026
$8.6M
Elucidating hallmarks of aging in the development of lower urinary tract dysfunction (LUTD)R01DK131175 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2021 to 2024
$2.3M
Estrogen pathways in the development of prostatic fibrosis and lower urinary tract dysfunctionR01DK127081 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2021 to 2024
$2.0M
NIDDK NIH HHS K12 DK100022NIDDK NIH HHS R01 DK127081NIDDK NIH HHS R01 DK131175NIDDK NIH HHS U54 DK104310
6 · The paper itself

Abstract

objectiveTo investigate the relationship between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) with functional and anatomic changes of the lower urinary tract with MRI. MATERIALS AND

methodsThe bladder and prostate of 95 subjects (56M, 39F) were segmented on T2-weighted pelvic MRI using Materialize Mimics 3D software. Bladder wall volume (BWV), post-void residual (PVR) and prostate volume (PV) were quantified from the 3D renderings. LUTS were quantified using validated questionnaires administered at the time of MRI. Wilcoxin rank sum, win ratio and chi-square tests were used to correlate symptom scores, BWV, PVR and PV in patients 1) without vs with MetS, 2) with mild (IPSS or UDI-6: 0-7) vs moderate-severe (IPSS: 8-35 or UDI-6: ≥8) and 3) normal vs enlarged prostates (>40cm

resultsMen with MetS had increased BWV (66.8 vs 51.1cm

conclusionMetS leads to detrusor hypertrophy and may contribute to impaired bladder function, likely related to the effect on the prostate.

Indexed as

Lower Urinary Tract SymptomsMetabolic SyndromeProstateUrinary BladderBody Mass IndexCorrelation of DataFemaleHumansHypertrophyMagnetic Resonance ImagingMaleMiddle AgedOrgan SizePrevalenceSymptom Assessment

Identifiers

PMID34571092
PMCPMC8760147
OpenAlexW3204433253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.