Evidence map›Paper›PMID 34571013›Full record

ArticleBiophysical journal2021

Vesicle Viewer: Online visualization and analysis of small-angle scattering from lipid vesicles.

Aislyn Lewis-Laurent, Milka Doktorova, Frederick A Heberle, Drew Marquardt

Abstract read
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Modification of Liposomal Properties by an Engineered Gemini Surfactant.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aislyn Lewis-LaurentDepartment of Chemistry & Biochemistry, University of Windsor, Windsor, Ontario, Canada.
Milka DoktorovaDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia.
Frederick A HeberleDepartment of Chemistry, University of Tennessee, Knoxville, Tennessee. Electronic address: fheberle@utk.edu.
Drew MarquardtDepartment of Chemistry & Biochemistry, University of Windsor, Windsor, Ontario, Canada; Department of Physics, University of Windsor, Windsor, Ontario, Canada. Electronic address: drew.marquardt@uwindsor.ca.

Funding

Coupling of lateral and transverse organization in complex biomembranesR01GM138887 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI HEBERLE, FREDERICK A, WAXHAM, M. NEAL · 2020 to 2023
$1.7M
Transient loss of plasma membrane asymmetry in mammalian cells: mechanisms and functionF32GM134704 · NIGMS · UNIVERSITY OF VIRGINIA · PI DOKTOROVA, MILKA · 2020 to 2022
$204k
NIGMS NIH HHS F32 GM134704NIGMS NIH HHS R01 GM138887
6 · The paper itself

Abstract

Small-angle X-ray and neutron scattering are among the most powerful experimental techniques for investigating the structure of biological membranes. Much of the critical information contained in small-angle scattering (SAS) data is not easily accessible to researchers who have limited time to analyze results by hand or to nonexperts who may lack the necessary scientific background to process such data. Easy-to-use data visualization software can allow them to take full advantage of their SAS data and maximize the use of limited resources. To this end, we developed an internet-based application called Vesicle Viewer to visualize and analyze SAS data from unilamellar lipid bilayer vesicles. Vesicle Viewer utilizes a modified scattering density profile (SDP) analysis called EZ-SDP in which key bilayer structural parameters, such as area per lipid and bilayer thickness, are easily and robustly determined. Notably, we introduce a bilayer model that is able to describe an asymmetric bilayer, whether it be chemically or isotopically asymmetric. The application primarily uses Django, a Python package specialized for the development of robust web applications. In addition, several other libraries are used to support the more technical aspects of the project; notable examples are Matplotlib (for graphs) and NumPy (for calculations). By eliminating the barrier of downloading and installing software, this web-based application will allow scientists to analyze their own vesicle scattering data using their preferred operating system. The web-based application can be found at https://vesicleviewer.dmarquardt.ca/.

Indexed as

Lipid BilayersNeutron DiffractionNeutronsScattering, Small AngleUnilamellar LiposomesLipid BilayersUnilamellar Liposomes

Identifiers

PMID34571013
PMCPMC8595566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.