Evidence map›Paper›PMID 34570991›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

An Updated Definition and Severity Classification of Chronic Obstructive Pulmonary Disease Exacerbations: The Rome Proposal.

Bartolome R Celli, Leonardo M Fabbri, Shawn D Aaron, Alvar Agusti, Robert Brook, Gerard J Criner, Frits M E Franssen, Marc Humbert, John R Hurst, Denis O'Donnell and 7 more

3 registry-linked trialsAbstract readHistorical Article
PubMed Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 200 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06147206 unknown statusnot on this mapstarted 2023, after this paper: background citation

"ANTES" Proposal: A New Approach to Exacerbation in COPD Patients. Exacerbantes Study.

TypeobservationalSponsorSociedad Española de Neumología y Cirugía TorácicaRan2023 to 2025Enrolled400ConditionsCOPD Exacerbation
NCT07125664 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Two-center, Randomized, Double-blind, Placebo-controlled Study of Intravenous Plasma-purified Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study)

TypeinterventionalSponsorFondazione IRCCS Policlinico San Matteo di PaviaRan2025 to 2027Enrolled36ConditionsAcute Exacerbation Chronic Obstructive Pulmonary DiseaseArmsalpha1-proteinase inhibitor, produced from the plasma of human donors (Prolastin 1000 mg, powder and solvent for solution for infusion), Placebo
NCT07185581 completednot on this mapstarted 2024, after this paper: background citation

Evaluation of Small Airway Function During COPD Exacerbation and Recovery Using Impulse Oscillometry (IOS) Device

Typeobservational_patient_registrySponsorDeniz BiliciRan2024 to 2024Enrolled41ConditionsCOPD Exacerbation, COPDArmsImpulse Oscillometry
3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  17. Appropriateness of antibiotic selection at emergency department discharge and risk of 30-day adverse events in patients with acute exacerbation of COPD.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Observational
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140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Bartolome R CelliDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-7266-8371
Leonardo M FabbriSection of Respiratory Medicine, Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy.
Shawn D AaronThe Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Alvar AgustiUniversitat de Barcelona, Barcelona, Spain.
Robert BrookWayne State University, Detroit, Michigan.
Gerard J CrinerDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Frits M E FranssenDepartment of Research and Education, CIRO, Horn, the Netherlands.
Marc HumbertService de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France.
John R HurstUCL Respiratory, University College London, London, United Kingdom.
Denis O'DonnellRespiratory Investigation Unit, Queens University and Kingston Health Sciences Centre, Kingston, Ontario, Canada.
Leonardo Pantoni"Luigi Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Alberto PapiSection of Respiratory Medicine, University of Ferrara, Ferrara, Italy.
Roberto Rodriguez-RoisinUniversitat de Barcelona, Barcelona, Spain.
Sanjay SethiJacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.
Antoni TorresUniversitat de Barcelona, Barcelona, Spain.ORCID 0000-0002-8643-2167
Claus F VogelmeierDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University Medical Center of Giessen and Marburg, Philipps University of Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany; and.
Jadwiga A WedzichaRespiratory Division, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Guidelines as TopicSeverity of Illness IndexSymptom Flare UpHistory, 19th CenturyHistory, 20th CenturyHistory, 21st CenturyHumansPulmonary Disease, Chronic ObstructiveSymptom Assessment

Identifiers

PMID34570991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.