Evidence map›Paper›PMID 34570965›Full record

ArticleInternational journal of immunogenetics2021

Estimating HLA haplotype frequencies from homozygous individuals - A Technical Report.

Susanne Seitz, Vinzenz Lange, Paul J Norman, Jürgen Sauter, Alexander H Schmidt

Abstract read
In one paragraph

Article in International journal of immunogenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A discrete time simulation model for kidney allocation in Germany.Transplant international : official journal of the European Society for Organ Transplantation · 2026
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  7. Experimental Data on PIRCHE and T-Cell Reactivity: HLA-DPB1-Derived Peptides Identified by PIRCHE-I Show Binding to HLA-A*02:01 in vitro and T-Cell Activation in vivo.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Article
  8. Article
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  10. Should results of HLA haplotype frequency estimations be normalized?International journal of immunogenetics · 2021
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Susanne SeitzDKMS, Tübingen, Germany.ORCID https://orcid.org/0000-0003-4420-0728
Vinzenz LangeDKMS Life Science Lab, Dresden, Germany.
Paul J NormanDivision of Biomedical Informatics and Personalized Medicine, Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jürgen SauterDKMS, Tübingen, Germany.ORCID https://orcid.org/0000-0001-8485-2945
Alexander H SchmidtDKMS, Tübingen, Germany.ORCID https://orcid.org/0000-0003-0979-5914

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic DataR01AI128775 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, STEVEN JOHN MACK · 2017 to 2026
$4.5M
NIAID NIH HHS R01 AI128775NIAID NIH HHS U01 AI090905
6 · The paper itself

Abstract

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation-maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.

Indexed as

HLA AntigensAllelesGene FrequencyHaplotypesHumansRegistriesHLA Antigensallele frequencydonor registryhaplotype frequencyHLAhomozygosity

Identifiers

PMID34570965
PMCPMC9131737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.