ReviewMicrobial biotechnology2022
Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances.
Review in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 140 citations in OpenAlex.
- Microbial Metabolic Strategies for Environmental Detoxification: From Enzymatic Mechanisms to Synthetic Biology and Omics.Applied biochemistry and biotechnology · 2026Review
- Blocking oxidation of α-hydrogens enables non-fluorinated solvents to achieve high-potential stability in lithium batteries.Nature chemistry · 2026Article
- Probiotic and Microbial Enzymatic Mechanisms for PFAS Detoxification.Probiotics and antimicrobial proteins · 2026Review
- QuEChERS-Based LC-MS/MS and HRMS Methods for PFAS Determination in Food: A Systematic Review.Foods (Basel, Switzerland) · 2026Review
- Current Research Advances and Future Prospects on Microbial Consortia for Sustainable PFAS Remediation.International journal of molecular sciences · 2026Review
- Microbial and molecular approaches for PFAS transformation in soils: prospects and limitations.RSC advances · 2026Review
- Biotransformation and partitioning of structurally different PFAS by wastewater microbial consortia.Environmental science : water research & technology · 2026Article
- Enriching microbes capable of fluorotelomer acid defluorination: thermodynamic constraints and experimental challenges.NPJ emerging contaminants · 2026Article
- Sustainable remediation strategies for emerging PFAS contaminants in water.RSC advances · 2025Review
- Fluoride triggers lysis inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative proteomic profile of Aspergillus niger in response to polytetrafluoroethylene and irradiated polytetrafluoroethylene for enhanced bioremoval.Biodegradation · 2025Article
- Per- and Polyfluoroalkyl Substances (PFAS): History, Current Concerns, and Future Outlook.Molecules (Basel, Switzerland) · 2025Review
- Investigating anaerobic digestion microbiome resilience to high PFOA and PFOS mixtures during cometabolism.Bioresource technology · 2025Article
- Emerging contaminants of perfluoroalkyl carboxylic acids (PFCAs): a review of sources, occurrence, and accumulation in plants.Environmental geochemistry and health · 2025Review
- Membrane-Modifying Effects of Perfluoroalkyl Substances in Model Bacterial Membranes.ACS omega · 2025Article
- Recent advances in microbial and bioelectrochemical strategies for degradation of per- and polyfluoroalkyl substances: mechanisms, limitations, and research opportunities.Biotechnology letters · 2025Review
- Biotransforming the "Forever Chemicals": Trends and Insights from Microbiological Studies on PFAS.Environmental science & technology · 2025Review
- Gallium Resistance inApplied microbiology (Basel, Switzerland) · 2025Article
- Enzymatic Degradation of PFAS: Current Status and Ongoing Challenges.ChemSusChem · 2025Review
- A q-RASAR approach for oral and inhalational toxicity prediction of perfluorinated and polyfluorinated compounds (PFCs) using rodent toxicity data.NAM journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly- and perfluorinated chemicals, including perfluorinated alkyl substances (PFAS), are pervasive in today's society, with a negative impact on human and ecosystem health continually emerging. These chemicals are now subject to strict government regulations, leading to costly environmental remediation efforts. Commercial polyfluorinated compounds have been called 'forever chemicals' due to their strong resistance to biological and chemical degradation. Environmental cleanup by bioremediation is not considered practical currently. Implementation of bioremediation will require uncovering and understanding the rare microbial successes in degrading these compounds. This review discusses the underlying reasons why microbial degradation of heavily fluorinated compounds is rare. Fluorinated and chlorinated compounds are very different with respect to chemistry and microbial physiology. Moreover, the end product of biodegradation, fluoride, is much more toxic than chloride. It is imperative to understand these limitations, and elucidate physiological mechanisms of defluorination, in order to better discover, study, and engineer bacteria that can efficiently degrade polyfluorinated compounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.