ArticleIEEE transactions on bio-medical engineering2022
Acoustic Holograms for Bilateral Blood-Brain Barrier Opening in a Mouse Model.
Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 63 citations in OpenAlex.
- Imaging of Neurovascular Activity during Motor Responses Evoked by Displacement-guided Focused Ultrasound (DgFUS) Neuromodulation in Mice.Research square · 2026Article
- Additive Manufacturing Techniques for Acoustic Hologram Lens Microfabrication.Micromachines · 2025Review
- All-optically controlled phased-array for ultrasonics.Nature communications · 2025Article
- Acoustic hologram-enabled simultaneous multi-target blood-brain barrier opening (AH-SiMBO).Communications engineering · 2025Article
- A Roadmap to Holographic Focused Ultrasound Approaches for Generating Gradient Thermal Patterns.International journal for numerical methods in biomedical engineering · 2025Article
- Evaluating the accuracy of acoustic holograms for precise spatial targeting within the brain.NPJ acoustics · 2025Article
- Bi-modal confirmation of liposome delivery to the brain after focused ultrasound-induced blood-brain barrier opening.Heliyon · 2024Article
- Feasibility of Hologram-Assisted Bilateral Blood-Brain Barrier Opening in Non-Human Primates.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Non-Invasive Blood-Brain Barrier Disruption Using Acoustic Holography With a Clinical Focused Ultrasound System.IEEE transactions on bio-medical engineering · 2024Article
- An all-ultrasound cranial imaging method to establish the relationship between cranial FUS incidence angle and transcranial attenuation in non-human primates in 3D.Scientific reports · 2024Article
- Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping.Theranostics · 2024Article
- Programmable Acoustic Holography using Medium-Sound-Speed Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Holographic Focused Ultrasound Hyperthermia System for Uniform Simultaneous Thermal Exposure of Multiple Tumor Spheroids.Cancers · 2023Article
- Emerging topics in nanophononics and elastic, acoustic, and mechanical metamaterials: an overview.Nanophotonics (Berlin, Germany) · 2023Review
- Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation.Brain stimulationArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Transcranial focused ultrasound (FUS) in conjunction with circulating microbubbles injection is the sole non-invasive technique that temporally and locally opens the blood-brain barrier (BBB), allowing targeted drug delivery into the central nervous system (CNS). However, single-element FUS technologies do not allow the simultaneous targeting of several brain structures with high-resolution, and multi-element devices are required to compensate the aberrations introduced by the skull. In this work, we present the first preclinical application of acoustic holograms to perform a bilateral BBB opening in two mirrored regions in mice. The system consisted of a single-element focused transducer working at 1.68 MHz, coupled to a 3D-printed acoustic hologram designed to produce two symmetric foci in anesthetized mice in vivo and, simultaneously, compensate the aberrations of the wavefront caused by the skull bones. T1-weighed MR images showed gadolinium extravasation at two symmetric quasi-spherical focal spots. By encoding time-reversed fields, holograms are capable of focusing acoustic energy with a resolution near the diffraction limit at multiple spots inside the skull of small preclinical animals. This work demonstrates the feasibility of hologram-assisted BBB opening for low-cost and highly-localized targeted drug delivery in the CNS in symmetric regions of separate hemispheres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.