Evidence map›Paper›PMID 34570623›Full record

ArticleJournal of bacteriology2021

Loss of Dihydroxyacid Dehydratase Induces Auxotrophy in Bacillus anthracis.

Joseph Jelinski, Madeline Cortez, Austen Terwilliger, Justin Clark, Anthony Maresso

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joseph JelinskiDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Madeline CortezDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Austen TerwilligerDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Justin ClarkDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Anthony MaressoDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Baylor College of Medicine · US

Funding

Nutrient Uptake during Anthrax DiseaseR01AI097167 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2012 to 2022
$3.5M
Branched Chain Amino Acid Metabolism During AnthraxR21AI146481 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2019 to 2020
$440k
The Importance and Function of Heme Degrading Enzymes during Anthrax DiseaseR21AI125778 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2017 to 2018
$436k
Targeting Heme Transporters for Improved Vaccines against AnthraxR21AI109465 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2015 to 2016
$435k
GENETIC BASIS FOR HOST SPECIFICITY IN SALMONELLAF32AI009465 · NIAID · WASHINGTON UNIVERSITY · PI MORROW, BRIAN J · 1996 to 1998
–
NIAID NIH HHS AI09465NIAID NIH HHS AI097167NIAID NIH HHS AI125778NIAID NIH HHS AI146481NIAID NIH HHS F32 AI009465NIAID NIH HHS R01 AI097167NIAID NIH HHS R21 AI109465NIAID NIH HHS R21 AI125778NIAID NIH HHS R21 AI146481
6 · The paper itself

Abstract

Anthrax disease is caused by infection with the bacteria Bacillus anthracis which, if left untreated, can result in fatal bacteremia and toxemia. Current treatment for infection requires prolonged administration of antibiotics. Despite this, inhalational and gastrointestinal anthrax still result in lethal disease. By identifying key metabolic steps that B. anthracis uses to grow in host-like environments, new targets for antibacterial strategies can be identified. Here, we report that the

Indexed as

AnimalsBacillus anthracisBlood ProteinsCulture MediaGene DeletionGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicHemoglobinsHumansHydro-LyasesMiceMutationBlood ProteinsCulture Mediadihydroxyacid dehydrataseHemoglobinsHydro-Lyasesamino acid dependencyanthraxauxotrophybacillusisoleucinenutrient acquisition

Identifiers

PMID34570623
PMCPMC8604071
OpenAlexW3201859083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.