ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2022
Hypersensitivity may be involved in severe COVID-19.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Effectiveness of comprehensive rehabilitation for functional recovery and symptom reduction in long COVID: results from a six‑month randomised controlled trial.Scientific reports · 2026Trial
- IgE Anti-Beta Coronaviruses Serology in Napoleon Soldiers, France.Journal of medical virology · 2026Article
- Novel insights into diagnosis and management of hyperreactivity: a narrative review.Journal of thoracic disease · 2025Review
- Frequency of IgE antibody response to SARS-CoV-2 RBD protein across different disease severity COVID19 groups.Virology journal · 2025Article
- Changes in Respiratory Sensitivity Status of Patients in a Hospital in Shanxi Province Before and After the COVID-19 Epidemic.Journal of asthma and allergy · 2025Article
- Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK.Nature communications · 2024Article
- Review
- Effect of omalizumab on inflammatory markers in COVID-19: an exploratory analysis of the COVID-19 immunologic antiviral therapy with omalizumab (CIAO) trial.Frontiers in medicine · 2024Article
- Diagnostic value of lung function tests in long COVID: analysis of positive bronchial provocation test outcomes.Frontiers in medicine · 2024Article
- Omalizumab may protect allergic patients against COVID-19: A systematic review.The World Allergy Organization journal · 2023Review
- Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines?Allergy · 2022Review
- The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study.Journal of clinical medicine · 2022Article
- Hypersensitivity may be involved in severe COVID-19.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Uncovering the Mast Cell Response toFrontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDeaths attributed to Coronavirus Disease 2019 (COVID-19) are mainly due to severe hypoxemic respiratory failure. Although the inflammatory storm has been considered the main pathogenesis of severe COVID-19, hypersensitivity may be another important mechanism involved in severe cases, which have a perfect response to corticosteroids (CS).
methodWe detected the serum level of anti-SARS-CoV-2-spike S1 protein-specific IgE (SP-IgE) and anti-SARS-CoV-2 nucleocapsid protein-specific IgE (NP-IgE) in COVID-19. Correlation of levels of specific IgE and clinical severity were analysed. Pulmonary function test and bronchial provocation test were conducted in early convalescence of COVID-19. We also obtained histological samples via endoscopy to detect the evidence of mast cell activation.
resultThe levels of serum SP-IgE and NP-IgE were significantly higher in severe cases, and were correlated with the total lung severity scores (TLSS) and the PaO
conclusionHypersensitivity may be involved in severe COVID-19.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.