Evidence map›Paper›PMID 34570198›Full record

ArticleThe Journal of cell biology2021

Hematopoietic progenitors polarize in contact with bone marrow stromal cells in response to SDF1.

Thomas Bessy, Adrian Candelas, Benoit Souquet, Khansa Saadallah, Alexandre Schaeffer, Benoit Vianay, Damien Cuvelier, Samy Gobaa, Cecilia Nakid-Cordero, Julien Lion and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. CXCR4 coordinates adhesion, migration, and development of human NK cells.bioRxiv : the preprint server for biology · 2026
    Article
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  10. Bone marrow vasculature advancedFrontiers in cardiovascular medicine · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Thomas Bessy *Cytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0001-9911-4400
Adrian Candelas *Cytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0003-1922-9350
Benoit SouquetCytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0001-5474-9752
Khansa SaadallahCytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0001-9570-5190
Alexandre SchaefferCytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0002-3196-0405
Benoit VianayCytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0003-1926-237X
Damien CuvelierSorbonne Université, Paris, France.ORCID 0000-0001-9875-1467
Samy GobaaGroup of Biomaterials and Microfluidics Core Facility, Institut Pasteur, Paris, France.
Cecilia Nakid-CorderoHuman Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0003-0722-7577
Julien LionHuman Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, Université de Paris, Institut de Recherche Saint Louis, Paris, France.
Jean-Christophe BoriesHuman Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, Université de Paris, Institut de Recherche Saint Louis, Paris, France.
Nuala MooneyHuman Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0002-3516-6882
Thierry JaffredoLaboratoire de Biologie du Développement, Centre national de la recherche scientifique, UMR 7622, Institut National de la Santé et de la Recherche Médicale U1156, Sorbonne Université, Institut de Biologie Paris-Seine, Paris, France.ORCID 0000-0002-8724-3261
Jerome LargheroUnité de Thérapie Cellulaire, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Louis, Center of Clinical Investigations in Biotherapies of Cancer CBT501, Institut National de la Santé et de la Recherche Médicale, Université de Paris, Paris, France.
Laurent BlanchoinCytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0001-8146-9254
Lionel FaivreUnité de Thérapie Cellulaire, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Louis, Center of Clinical Investigations in Biotherapies of Cancer CBT501, Institut National de la Santé et de la Recherche Médicale, Université de Paris, Paris, France.ORCID 0000-0002-4353-127X
Stephane BrunetCytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0003-1990-1477
Manuel ThéryCytomorpho Lab, Human Immunology, Pathophysiology, Immunotherapy, Unit 976, Institut National de la Santé et de la Recherche Médicale, CEA, Assistance Publique - Hôpitaux de Paris, Université de Paris, Institut de Recherche Saint Louis, Paris, France.ORCID 0000-0002-9968-1779
Inserm · FRInstitut Pasteur · FRSorbonne Université · FRUniversité Sorbonne Nouvelle · FR

Funding

European Research Council ERC CoG 771599
6 · The paper itself

Abstract

The fate of hematopoietic stem and progenitor cells (HSPCs) is regulated by their interaction with stromal cells in the bone marrow. However, the cellular mechanisms regulating HSPC interaction with these cells and their potential impact on HSPC polarity are still poorly understood. Here we evaluated the impact of cell-cell contacts with osteoblasts or endothelial cells on the polarity of HSPC. We found that an HSPC can form a discrete contact site that leads to the extensive polarization of its cytoskeleton architecture. Notably, the centrosome was located in proximity to the contact site. The capacity of HSPCs to polarize in contact with stromal cells of the bone marrow appeared to be specific, as it was not observed in primary lymphoid or myeloid cells or in HSPCs in contact with skin fibroblasts. The receptors ICAM, VCAM, and SDF1 were identified in the polarizing contact. Only SDF1 was independently capable of inducing the polarization of the centrosome-microtubule network.

Indexed as

Bone MarrowCells, CulturedChemokine CXCL12Endothelial CellsHematopoietic Stem CellsHumansMesenchymal Stem CellsChemokine CXCL12CXCL12 protein, human

Identifiers

PMID34570198
PMCPMC8479938
OpenAlexW3203781497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.