Evidence map›Paper›PMID 34570185›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2022

Resting Energy Expenditure and Cold-induced Thermogenesis in Patients With Overt Hyperthyroidism.

Claudia I Maushart, Jaël R Senn, Rahel C Loeliger, Judith Siegenthaler, Fabienne Bur, Jonas G W Fischer, Matthias J Betz

Open access · hybridAbstract readClinical Trial, Phase IV
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Claudia I MaushartDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Jaël R SennDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Rahel C LoeligerDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Judith SiegenthalerDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Fabienne BurDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Jonas G W FischerDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Matthias J BetzDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.ORCID 0000-0002-6946-1871
University of Basel · CH

Funding

Swiss National Science Foundation PZ00P3_167823
6 · The paper itself

Abstract

contextThyroid hormone (TH) is crucial for the adaptation to cold.

objectiveTo evaluate the effect of hyperthyroidism on resting energy expenditure (REE), cold-induced thermogenesis (CIT) and changes in body composition and weight.

methodsThis was a prospective cohort study at the endocrine outpatient clinic of a tertiary referral center. Eighteen patients with overt hyperthyroidism were included. We measured REE during hyperthyroidism, after restoring euthyroid TH levels and after 3 months of normal thyroid function. In 14 of the 18 patients, energy expenditure (EE) was measured before and after a mild cold exposure of 2 hours and CIT was the difference between EEcold and EEwarm. Skin temperatures at 8 positions were recorded during the study visits. Body composition was assessed by dual X-ray absorption.

resultsFree thyroxine (fT4) and free triiodothyronine (fT3) decreased significantly over time (fT4, P = .0003; fT3, P = .0001). REE corrected for lean body mass (LBM) decreased from 42 ± 6.7 kcal/24 hour/kg LBM in the hyperthyroid to 33 ± 4.4 kcal/24 hour/kg LBM (-21%, P < .0001 vs hyperthyroid) in the euthyroid state and 3 months later to 33 ± 5.2 kcal/24 hour/kg LBM (-21%, P = .0022 vs hyperthyroid, overall P < .0001). fT4 (P = .0001) and fT3 (P < 0.0001) were predictors of REE. CIT did not change from the hyperthyroid to the euthyroid state (P = .96). Hyperthyroidism led to increased skin temperature at warm ambient conditions but did not alter core body temperature, nor skin temperature after cold exposure. Weight regain and body composition were not influenced by REE and CIT during the hyperthyroid state.

conclusionCIT is not increased in patients with overt hyperthyroidism.

Indexed as

ThermogenesisAdrenergic AntagonistsAdultAgedBasal MetabolismBody CompositionCold TemperatureFemaleHumansHyperthyroidismMaleMiddle AgedProspective StudiesThyroid Function TestsThyroxineTriiodothyronineAdrenergic AntagonistsThyroxineTriiodothyroninebrown adipose tissuecold induced thermogenesisenergy expenditurehyperthyroidismthyroid hormone

Identifiers

PMID34570185
PMCPMC8764338
OpenAlexW3204730538

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.