SynthesiseLife2021
Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia.
Synthesis in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Culture Shapes the Neural Functional Alteration and Its Development in Children With Dyslexia: A Cross-Linguistic Meta-Analysis.Developmental science · 2026Pooled it
- Emerging technologies and neuroscience-based approaches in dyslexia: a narrative review toward integrative and personalized solutions.Frontiers in human neuroscience · 2025Pooled it
- Toward an Improved Understanding of Dyslexia: Reflections on a New Consensus Definition and Its Implications.Dyslexia (Chichester, England) · 2026Article
- Cognitive Training Combined with Multifocal tDCS over the Reading Network Improves Reading Performance: A Case of Severe Dyslexia.Journal of clinical medicine · 2025Article
- Brain Changes Following Two Reading Interventions in Chinese Children With Reading Disability.Developmental science · 2025Article
- Toward a Mechanistic Understanding of Reading Difficulties: Deviant Audiovisual Learning Dynamics and Network Connectivity in Children with Poor Reading Skills.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Non-right-handedness, male sex, and regional, network-specific, ventral occipito-temporal anomalous lateralization in adults with a history of reading disability.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Revisiting atypical language lateralization in dyslexia.Brain communications · 2025Article
- No Support for White Matter Alterations in Adults With Dyslexia: A Fixel-Based Diffusion MRI Study.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Abnormal brain activation during speech perception and production in children and adults with reading difficulty.NPJ science of learning · 2024Article
- Clinical implications of brain asymmetries.Nature reviews. Neurology · 2024Review
- Exploring brain plasticity in developmental dyslexia through implicit sequence learning.NPJ science of learning · 2024Article
- Neural substrates of L2-L1 transfer effects on phonological awareness in young Chinese-English bilingual children.NeuroImage · 2024Article
- Age-related changes in individuals with and without reading disability: Behavioral and fMRI evidence.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A scoping review of utilization of the verbal fluency task in Chinese and Japanese clinical settings with near-infrared spectroscopy.Frontiers in psychiatry · 2024Article
- Cerebellar Neuromodulation Impacts Reading Fluency in Young Adults.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Disrupted network interactions serve as a neural marker of dyslexia.Communications biology · 2023Article
- Language Experience Modulates the Visual N200 Response for Disyllabic Chinese Words: An Event-Related Potential Study.Brain sciences · 2023Article
- Phonological and morphological literacy skills in English and Chinese: A cross-linguistic neuroimaging comparison of Chinese-English bilingual and monolingual English children.Human brain mapping · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and functional abnormalities are consistent/inconsistent across languages. In the current multimodal meta-analysis, we found convergent structural and functional alterations in the left superior temporal gyrus across languages, suggesting a neural signature of DD. We found greater reduction in grey matter volume and brain activation in the left inferior frontal gyrus in morpho-syllabic languages (e.g. Chinese) than in alphabetic languages, and greater reduction in brain activation in the left middle temporal gyrus and fusiform gyrus in alphabetic languages than in morpho-syllabic languages. These language differences are explained as consequences of being DD while learning a specific language. In addition, we also found brain regions that showed increased grey matter volume and brain activation, presumably suggesting compensations and brain regions that showed inconsistent alterations in brain structure and function. Our study provides important insights about the etiology of DD from a cross-linguistic perspective with considerations of consistency/inconsistency between structural and functional alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.