Evidence map›Paper›PMID 34569888›Full record

ArticleDrug delivery2021

Wettability and contact angle affect precorneal retention and pharmacodynamic behavior of microspheres.

Hanyu Liu, Xinyue Han, Huamei Li, Qi Tao, Jie Hu, Shuo Liu, Huaixin Liu, Jun Zhou, Wei Li, Fan Yang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Microsphere-loaded dual-responseJournal of pharmaceutical analysis · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Hanyu LiuGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Xinyue HanGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Huamei LiGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Qi TaoCAS Key Laboratory of Mineralogy and Metallogeny & Guangdong Provincial Key Laboratory of Mineral Physics and Materials, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences (CAS), Guangzhou, China.
Jie HuGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Shuo LiuGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Huaixin LiuGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Jun ZhouDepartment of English Language and Literature, University College London, London, UK.
Wei LiGuangzhou Institute For Drug Control, Guangzhou, China.
Fan YangGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Qineng PingCollege of Pharmacy, China Pharmaceutical University, Nanjing, China.
Shijie WeiGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Hongmei LiuCAS Key Laboratory of Mineralogy and Metallogeny & Guangdong Provincial Key Laboratory of Mineral Physics and Materials, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences (CAS), Guangzhou, China.
Huaqing LinGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Dongzhi HouGuangdong Engineering and Technology Research Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Guangdong Pharmaceutical University · CNGuangzhou Institute of Geochemistry · CNChina Pharmaceutical University · CNGuangdong Institute for Drug Control · CNUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we describe the development of betaxolol hydrochloride and montmorillonite with ion exchange in a single formulation to create a novel micro-interactive dual-functioning sustained-release delivery system (MIDFDS) for the treatment of glaucoma. Betaxolol hydrochloride molecule was loaded onto the montmorillonite by ion exchange and MIDFDS formation was confirmed by XPS data. MIDFDS showed similar physicochemical properties to those of Betoptic, such as particle size, pH, osmotic pressure, and rheological properties. Nevertheless, the microdialysis and intraocular pressure test revealed better

Indexed as

MicrospheresWettabilityAnimalsBentoniteBetaxololCell SurvivalChemistry, PharmaceuticalDelayed-Action PreparationsDrug CarriersDrug LiberationFemaleHemolysisHydrogen-Ion ConcentrationIntraocular PressureMaleParticle SizeBentoniteBetaxololDelayed-Action PreparationsDrug Carrierscontact angleEudragitGlaucomamicrospheremontmorillonite

Identifiers

PMID34569888
PMCPMC8480260
OpenAlexW3202652444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.