Evidence map›Paper›PMID 34569643›Full record

ArticleThe EMBO journal2021

A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress.

Verena Hurst, Kiran Challa, Felix Jonas, Romain Forey, Ragna Sack, Jan Seebacher, Christoph D Schmid, Naama Barkai, Kenji Shimada, Susan M Gasser and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  5. A DNA damage-induced phosphorylation circuit enhances Mec1Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Verena HurstFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0002-8521-1899
Kiran ChallaFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0001-7141-1841
Felix JonasDepartments of Molecular Genetics and Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
Romain ForeyInstitut de Génétique Humaine, CNRS, Université de Montpellier, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Ragna SackFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0003-0963-8089
Jan SeebacherFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0002-7858-2720
Christoph D SchmidFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Naama BarkaiDepartments of Molecular Genetics and Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
Kenji ShimadaFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0002-6670-3118
Susan M GasserFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0003-3610-9123
Jérôme PoliFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0001-8091-5507
Friedrich Miescher Institute · CHCentre National de la Recherche Scientifique · FRUniversity of Basel · CHWeizmann Institute of Science · ILUniversity of Augsburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upon replication stress, budding yeast checkpoint kinase Mec1

Indexed as

DNA ReplicationProtein Processing, Post-TranslationalChromatinGalactokinaseGene Expression Regulation, FungalHydroxyureaIntracellular Signaling Peptides and ProteinsPhosphoproteinsPhosphorylationProtein Serine-Threonine KinasesRNA Polymerase IIRNA Polymerase IIISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS PhaseStress, PhysiologicalChromatinGAL1 protein, S cerevisiaeGalactokinaseHydroxyureaIntracellular Signaling Peptides and ProteinsMEC1 protein, S cerevisiaePhosphoproteinsProtein Serine-Threonine KinasesRNA Polymerase IIRNA Polymerase IIIRPB3 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsMec1nuclear porereplication checkpointreplication interferencereplication stresstranscription

Identifiers

PMID34569643
PMCPMC8561635
OpenAlexW3204310017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.