ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Intrinsic Capacity Predicts Negative Health Outcomes in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Transitions and trajectories in intrinsic capacity states over time: a systematic review.BMC geriatrics · 2025Pooled it
- Qualitative Comparative Analysis of exercise interventions for fall prevention in residential aged care facilities.BMC geriatrics · 2024Pooled it
- Prevalence of intrinsic capacity decline among community-dwelling older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Detection rate of decreased intrinsic capacity of older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- Intrinsic capacity and self-perceived health among home-dwelling older adults: The HUNT study.The Journal of frailty & aging · 2026Article
- Intrinsic capacity trajectories and health outcomes in home care settings: a Canadian population-based cohort study.Age and ageing · 2026Article
- Association between sedentary time and intrinsic capacity among community-dwelling older adults: evidence from a prospective BLINDSCE cohort.GeroScience · 2026Article
- Intrinsic capacity and the physical frailty phenotype as complementary predictors of mortality in older Indian adults.Research square · 2026Article
- Intrinsic capacity and survival among older adults in India: LASI-DAD study (wave 1 and wave 2).The Lancet regional health. Southeast Asia · 2026Article
- Association between intrinsic capacity and dementia risk in older Mexicans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Fun Exercise for Older Adults (FEXO): study protocol for a randomised controlled trial on intrinsic capacity, adherence and motivation.BMJ open · 2026Article
- Intrinsic capacity and the risk of adverse health outcomes in older adults: a population-based study.BMC geriatrics · 2026Article
- The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo Study for Healthy Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association between intrinsic capacity and disability before death among older adults: a decedent cohort study.The lancet. Healthy longevity · 2026Article
- Living space, utilities, and communication access as determinants of intrinsic capacity: longitudinal findings from England and China.BMC geriatrics · 2026Article
- Adapting the WHO ICOPE framework to design an integrated frailty and intrinsic capacity management community-based programme in Singapore: a programme description using the updated and modified TIDieR checklist.BMC health services research · 2026Article
- Article
- Development and internal validation of a nomogram for identifying intrinsic capacity impairment among community-dwelling older adults in China: a cross-sectional study.BMC geriatrics · 2026Article
- Intrinsic capacity trajectory and hip fracture risk in Chinese middle-aged and older adults: a 10-year retrospective cohort study.Scientific reports · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMonitoring trajectories of intrinsic capacity (IC) in older adults has been suggested by the World Health Organization as a means to inform prevention to avoid or delay negative health outcomes. Due to a lack of longitudinal studies, it is currently unclear how IC changes over time and whether repeatedly measured IC predicts negative health outcomes.
methodsBased on 4 751 repeated observations of IC (range = 0-100) during 21 years of follow-up among 754 older adults 70 and older, we assessed longitudinal trajectories of IC, and whether time-varying IC predicted the risk of chronic activities of daily living disability, long-term nursing home stay, and mortality using joint models.
resultsAverage IC declined progressively from 77 to 11 points during follow-up, with substantial heterogeneity between older adults. Adjusted for sociodemographics and chronic diseases, a 1-point lower IC value was associated with a 7% increase in the risk of activities of daily living disability, a 6% increase in the risk of a nursing home stay, and a 5% increase in mortality. Accuracy for 5- and 10-year predictions based on up to 3 repeated measurements of IC ranged between moderate and good (area under the receiver operating characteristic curve = 0.76-0.82).
conclusionsOur study indicates that IC declines progressively and that it predicts negative health outcomes among older adults. Therefore, regular monitoring of IC could work as an early warning system informing preventive efforts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.